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1.发明授权公开(公告)号：US08048647B2
公开(公告)日：2011-11-01
申请号：US12635994
申请日：2009-12-11
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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2.发明授权公开(公告)号：US07371549B2
公开(公告)日：2008-05-13
申请号：US11362915
申请日：2006-02-28
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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3.发明授权公开(公告)号：US07241599B2
公开(公告)日：2007-07-10
申请号：US11146093
申请日：2005-06-07
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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4.发明申请Novel aldolase, and method for producing optically active IHOG and monatin 失效新型醛缩酶，以及用于制备光学活性的IHOG和莫纳甜的方法公开(公告)号：US20060172396A1
公开(公告)日：2006-08-03
申请号：US11362915
申请日：2006-02-28
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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5.发明授权公开(公告)号：US07662596B2
公开(公告)日：2010-02-16
申请号：US11953372
申请日：2007-12-10
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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公开(公告)号：US20060003426A1
公开(公告)日：2006-01-05
申请号：US11146093
申请日：2005-06-07
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
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7.发明申请NOVEL ALDOLASE, AND METHOD FOR PRODUCING OPTICALLY ACTIVE IHOG AND MONATIN 失效新型ALDOLASE和用于生产光学活性的IHOG和MONATIN的方法公开(公告)号：US20090258403A1
公开(公告)日：2009-10-15
申请号：US11953372
申请日：2007-12-10
IPC分类号： C12P17/10
摘要： The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As such, the present invention enables the synthesis of 4-(Indole-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid with high optical purity, which is useful as an intermediate in the synthesis of optically active monatin, from indole pyruvic acid and pyruvic acid (or oxaloacetic acid).
摘要翻译： 本发明涉及一种用于制备光学活性的IHOG的方法，其可以用于制备莫纳甜。 本发明还涉及用于制备光学活性莫纳甜的方法和用于这些方法的醛缩酶。 因此，本发明能够合成具有高光学纯度的4-（吲哚-3-基甲基）-4-羟基-2-氧代戊二酸，其可用作在光学活性莫纳甜的合成中的吲哚丙酮酸的中间体 酸和丙酮酸（或草酰乙酸）。
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公开(公告)号：US20080193984A1
公开(公告)日：2008-08-14
申请号：US11576421
申请日：2005-09-29
CPC分类号： C12P13/227 , C12P13/04 , C12R1/01 , C12R1/185 , C12R1/19
摘要： The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I): wherein R1 represents an optionally substituted predetermined hydrocarbon group; R2 represents a C1 to C3 alkyl group or a hydrogen atom; and n is 0 or 1, to produce an amino acid derivative represented by the following general formula (III): wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.
摘要翻译： 本发明提供一种工业上有利的氨基酸衍生物的制备方法。 本发明提供一种氨基酸衍生物的制造方法，其包括使微生物和/或酶与下述通式（I）表示的羟基亚氨酸接触：其中R 1表示任选取代的预定烃基 ; R 2表示C1〜C3烷基或氢原子; 并且n为0或1，以产生由以下通式（III）表示的氨基酸衍生物：其中R 1和n与R 1的那些具有相同的含义。 和通式（I）中的n，其中微生物和/或酶能够催化该反应。
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公开(公告)号：US08043836B2
公开(公告)日：2011-10-25
申请号：US11576421
申请日：2005-09-29
IPC分类号： C12P1/00 , C12P13/04 , C12P13/22 , C12P17/10 , C07D209/18
CPC分类号： C12P13/227 , C12P13/04 , C12R1/01 , C12R1/185 , C12R1/19
摘要： The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by the following general formula (I): wherein R1 represents an optionally substituted predetermined hydrocarbon group; R2 represents a C1 to C3 alkyl group or a hydrogen atom; and n is 0 or 1, to produce an amino acid derivative represented by the following general formula (III): wherein R1 and n have the same meanings as those of R1 and n in the general formula (I), wherein the microorganism and/or the enzyme is capable of catalyzing the reaction.
摘要翻译： 本发明提供一种工业上有利的氨基酸衍生物的制备方法。 本发明提供一种生产氨基酸衍生物的方法，其包括使微生物和/或酶与由以下通式（I）表示的肟基酸接触：其中R1表示任选取代的预定烃基; R2表示C1〜C3烷基或氢原子; 和n为0或1，以产生由以下通式（III）表示的氨基酸衍生物：其中R 1和n与通式（I）中的R 1和n的含义相同，其中微生物和/ 或者酶能够催化反应。
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公开(公告)号：US20120270279A1
公开(公告)日：2012-10-25
申请号：US13271280
申请日：2011-10-12
申请人： Yasuaki Takakura , Hiroomi Ogino , Masakazu Sugiyama , Kenichi Mori , Eri Tabuchi , Koki Ishikawa , Uno Tagami , Hidemi Fujii
发明人： Yasuaki Takakura , Hiroomi Ogino , Masakazu Sugiyama , Kenichi Mori , Eri Tabuchi , Koki Ishikawa , Uno Tagami , Hidemi Fujii
CPC分类号： C12P13/04 , C12N9/1096 , C12P17/10
摘要： The present invention provides a methodology for improving a yield of 2R,4R-Monatin. Specifically, the present invention provides a method for producing 2S,4R-Monatin or a salt thereof, comprising contacting 4R-IHOG with an L-amino acid aminotransferase in the presence of an L-amino acid to form the 2S,4R-Monatin; a method for producing 2R,4R-Monatin or a salt thereof, comprising isomerizing the 2S,4R-Monatin to form the 2R,4R-Monatin; and the like. These production methods may further comprise condensing indole-3-pyruvate and pyruvate to form the 4R-IHOG, and deaminating a tryptophan to form the indole-3-pyruvate.
摘要翻译： 本发明提供了提高2R，4R-莫纳甜产率的方法。 具体地说，本发明提供了制备2S，4R-莫纳甜或其盐的方法，包括在L-氨基酸的存在下将4R-1HOG与L-氨基酸氨基转移酶接触以形成2S，4R-莫纳甜; 一种制备2R，4R-莫纳甜或其盐的方法，包括使2S，4R-莫纳甜异构化形成2R，4R-莫纳甜; 等等。 这些制备方法还可以包括将吲哚-3-丙酮酸和丙酮酸缩合形成4R-1HOG，并使色氨酸脱氨基形成吲哚-3-丙酮酸盐。
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