发明申请
- 专利标题: DEVICE AND A METHOD FOR PROMOTING CRYSTALLISATION
- 专利标题(中): 装置和促进结晶的方法
-
申请号: US12303132申请日: 2007-06-27
-
公开(公告)号: US20090264632A1公开(公告)日: 2009-10-22
- 发明人: Morten Sommer
- 申请人: Morten Sommer
- 优先权: DKPA200600863 20060628
- 国际申请: PCT/DK07/50078 WO 20070627
- 主分类号: C07K1/30
- IPC分类号: C07K1/30 ; B01D9/00 ; C07H1/06 ; C07H21/00
摘要:
The invention relates to a microfluidic device for promoting crystallisation of target molecules, such as proteins. The device comprises a solid structure with a top face and an opposite bottom face and with a least one liquid channel. The liquid channel comprises a target molecule solution inlet and at least two precipitant inlets. The target molecule solution inlet is in liquid communication with each of the precipitant inlets through the liquid channel. The liquid channel comprises a branching channel section adjacent to the target molecule solution inlet, crystallisation channel sections adjacent to the respective precipitant inlets and flow break channel sections arranged between the branching channel section and each of the crystallization channel sections. The liquid channel is branched from 1 to X in the branching channel section, wherein X is the number of crystallisation channel sections, and the flow break channel sections comprise a flow break arrangement capable of breaking up the liquid communication between said respective branching channel section and crystallisation channel sections.
公开/授权文献
- US08986449B2 Device and a method for promoting crystallisation 公开/授权日:2015-03-24
信息查询