发明申请
- 专利标题： Novel Gene Disruptions, Compositions and Methods Relating Thereto
- 专利标题（中）： 新型基因中断，组成和方法
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申请号： US11814025申请日： 2007-04-18
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公开(公告)号： US20090288176A1公开(公告)日： 2009-11-19
- 发明人: Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
- 申请人： Kristi Rae Bollinger , Frederic J. de Sauvage , Joel Edwards , Rosemary Girgis , Leslie Jane Green , Laurie Jeanette Minze , Bobby Joe Payne , Carolina Rangel , Zheng-Zheng Shi , Mary Jean Sparks , Tracy Tzu-Ling Tang , Peter Vogel
- 申请人地址： US CA South San Francisco
- 专利权人： Genentech, Inc.
- 当前专利权人： Genentech, Inc.
- 当前专利权人地址： US CA South San Francisco
- 国际申请： PCT/US07/66886 WO 20070418
- 主分类号： G01N33/00
- IPC分类号： G01N33/00 ; A61K39/395 ; C12N5/10 ; C07K16/00 ; A01K67/00
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO286, PRO706, PRO1800, PRO4354, PRO6029, PRO9739, PRO20044, PRO28631 or PRO34128 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
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