发明申请
- 专利标题: PROCESS FOR THE PREPARATION OF GABAPENTIN
- 专利标题(中): 制备GABAPENTIN的方法
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申请号: US12400080申请日: 2009-03-09
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公开(公告)号: US20090326266A1公开(公告)日: 2009-12-31
- 发明人: Katiuscia ARRIGHI , Vincenzo CANNATA , Francesco CORCELLA , Gaetano MARCHIORO , Andrea NICOLI , Maurizio PAIOCCHI , Marco VILLA
- 申请人: Katiuscia ARRIGHI , Vincenzo CANNATA , Francesco CORCELLA , Gaetano MARCHIORO , Andrea NICOLI , Maurizio PAIOCCHI , Marco VILLA
- 申请人地址: IT Bresso (Milano)
- 专利权人: ZACH SYSTEM S.p.A.
- 当前专利权人: ZACH SYSTEM S.p.A.
- 当前专利权人地址: IT Bresso (Milano)
- 优先权: ITMI2003A002165 20031111
- 主分类号: C07C229/28
- IPC分类号: C07C229/28
摘要:
A process for the preparation of 1,1-cyclohexanediacetic acid monoamide comprising the amination of 1,1-cyclohexanediacetic acid anhydride by reaction with aqueous NH3 at a temperature lower than 30° C. by using a NH3/anhydride molar ratio lower than 3, and the product precipitation through the acidification of the reaction mixture; a precipitation process of 1,1-cyclohexanediacetic acid monoamide; and a process for the synthesis of gabapentin comprising the above preparation of 1,1-cyclohexanediacetic acid monoamide, the Hofmann transposition of the same monoamide, the purification of a gabapentin salt and the crystallization from organic solvent.