摘要:
An electro-optic device 200 comprising a substrate in which first and second waveguides 202, 203 are formed. The device also comprises first and second electrodes 204, 205 comprising an optically transparent conductive material and including primary portions 204a, 205a overlying the first and second waveguides 202, 203 for electrically biasing the first and second waveguides. The device is configured such that one of the first and second electrodes includes one other portion 204b, 205b arranged alongside the primary portion 204a, 205a of the other of the first and second electrodes. This arrangement improves the electro-optic efficiency of the device without the need for a buffer layer in the electrodes.
摘要:
The present invention relates to a new process for the preparation of the (S)-naproxen 4-nitrooxybutyl ester and to new intermediates obtained and used therein. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active compounds such as (S)-naproxen 4-nitrooxybutyl ester. The invention also relates to the use of (S)-naproxen 4-nitrooxybutyl ester prepared according to the process of the present invention for the manufacturing of a medicament for the treatment of pain.
摘要:
A process for preparing Anastrozole is provided. In the process the steps of a. combining 3,5-bis(2-cyanoisopropyl)toluene, a solvent selected from the group consisting of acetonitrile, dichloromethane and chlorobenzene, a brominating reagent selected from a group consisting of N-bromosuccinimide and 1,3-dibromo-5,5-dimethylhydantoin, and 2,2′-azobis(2-methylpropionitrile); b. heating; c. combining with 1,2,4-triazole, a solvent selected from a group consisting of N-methylpyrrolidinone, dimethylformamide, mixtures of NMP and DMF, dimethylsulfoxide, mixtures of DMSO and toluene, acetone, ACN, and tetrahydrofuran, a base selected from a group consisting of NaOH, KOH, K2CO3, and Na2CO3, and 1,3-benzendiacetonitrile-5-(bromomethyl)-α,α,{acute over (α)},{acute over (α)}-tetramethyl, at a temperature below −20° C. are performed.
摘要翻译:提供了制备阿那曲唑的方法。 在这个过程中,a。 结合3,5-双(2-氰基异丙基)甲苯,选自乙腈,二氯甲烷和氯苯的溶剂,选自N-溴代琥珀酰亚胺和1,3-二溴-5,5-二氯苯的溴化试剂, 二甲基乙内酰脲和2,2'-偶氮双(2-甲基丙腈); b。 加热; C。 与1,2,4-三唑组合,选自N-甲基吡咯烷酮,二甲基甲酰胺,NMP和DMF的混合物,二甲基亚砜,DMSO和甲苯的混合物,丙酮,ACN和四氢呋喃的溶剂,选自 由NaOH,KOH,K 2 CO 3和Na 2 CO 3组成的组,和1,3-苯撑二乙腈-5-(溴甲基)-α,α,(急性(α)},{急(α)} - 低于-20℃。
摘要:
Provided are crystalline forms of N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid, pemetrexed diacid, and processes for the preparation thereof.
摘要:
A process for the nitration of conjugated alkenes of formula (I) wherein R, R1, R2, R3 and R4 have the meanings reported in the description, which allows to obtain the corresponding β-nitro-alkenes, characterised in that the nitrating agent is a mixture of an inorganic nitrite and iodine in the presence of an oxidising agent is described.
摘要:
Novel forms of crystalline docetaxel are provided, as well as pharmaceutical compositions, and methods of treatment. Novel processes for making crystalline docetaxel are also provided.
摘要:
The present invention relates to a new process for the preparation of NO-donating compounds using a sulfonated intermediate. The invention relates to new intermediates prepared therein suitable for large scale manufacturing of NO-donating compounds. The invention further relates to the use of the new intermediates for the manufacturing of pharmaceutically active NO-donating compounds. The invention further relates to a substantially crystalline form of NO-donating NSAIDs, especially 2-[2-(nitrooxy)ethoxy]ethyl {2-[(2,6-dichlorophenyl)amino]phenyl}acetate, the preparation thereof and to pharmaceutical formulations containing said crystalline form and to the use of said crystalline form in the preparation of a medicament.