发明申请
US20100041107A1 METHOD OF REDUCING GENE EXPRESSION USING MODIFIED CODON USAGE
审中-公开
使用改性CODON使用减少基因表达的方法
- 专利标题： METHOD OF REDUCING GENE EXPRESSION USING MODIFIED CODON USAGE
- 专利标题（中）： 使用改性CODON使用减少基因表达的方法
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申请号： US12446767申请日： 2007-10-18
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公开(公告)号： US20100041107A1公开(公告)日： 2010-02-18
- 发明人: Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Osker Zelder , Weol Kyu Jeong
- 申请人： Andrea Herold , Corinna Klopprogge , Hartwig Schröder , Osker Zelder , Weol Kyu Jeong
- 申请人地址： DE Ludwigshafen
- 专利权人： BASF SE
- 当前专利权人： BASF SE
- 当前专利权人地址： DE Ludwigshafen
- 优先权： EP06122882.1 20061024
- 国际申请： PCT/EP2007/061151 WO 20071018
- 主分类号： C12P13/12
- IPC分类号： C12P13/12 ; C12P1/00 ; C12P13/04 ; C12P13/08 ; C12P7/64 ; C12N5/10 ; C12N5/04 ; C12N1/21 ; C12N15/00 ; C12N15/11
摘要：
The present invention is directed to a method of reducing the amount of at least one polypeptide in a host cell by expressing a nucleotide sequence encoding for the polypeptide in the host cell wherein the nucleotide sequence uses codons that are rarely used according to the codon usage of the host organism. Furthermore, the present invention relates to nucleotide sequences encoding for a polypeptide with a codon usage that has been adjusted to use codons that are only rarely used according to the codon usage of the host organism. The present invention further relates to the use of such sequences and methods for producing fine chemicals such as amino acids, sugars, lipids, oils, carbohydrates, vitamins, cofactors etc.
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