发明申请
US20100048628A1 METHOD FOR SUPPRESSING DISCOLORATION OVER TIME OF ADHESIVE PREPARATION CONTAINING DONEPEZIL
审中-公开
用于抑制含有二苯醚的胶粘剂制备时间的消除方法
- 专利标题: METHOD FOR SUPPRESSING DISCOLORATION OVER TIME OF ADHESIVE PREPARATION CONTAINING DONEPEZIL
- 专利标题(中): 用于抑制含有二苯醚的胶粘剂制备时间的消除方法
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申请号: US12517004申请日: 2007-11-30
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公开(公告)号: US20100048628A1公开(公告)日: 2010-02-25
- 发明人: Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
- 申请人: Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
- 优先权: JP2006-325104 20061201; JP2007-152016 20070607; JP2007-152047 20070607
- 国际申请: PCT/JP2007/073254 WO 20071130
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; A61P25/28
摘要:
[Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.
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