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1.发明申请METHOD FOR SUPPRESSING COLORING OF ADHESIVE PREPARTION CONTAINING DONEPEZIL AND METHOD FOR REDUCING AMOUNTS OF DONEPEZIL-RELATED SUBSTANCES FORMED 审中-公开用于抑制含有二苯醚的粘合制剂的着色方法和减少形成的与二苯醚相关的物质的量的方法公开(公告)号：US20100062045A1
公开(公告)日：2010-03-11
申请号：US12516998
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61K9/70 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] By suppressing coloring of an adhesive preparation containing donepezil, a naturally colored appearance is realized.[Solution] In a method for suppressing coloring of an adhesive preparation having a support and a pressure-sensitive adhesive layer, which comprises a pressure-sensitive adhesive and donepezil in the pressure-sensitive adhesive layer, ascorbic acid, a metal salt or an ester thereof and metal metabisulfite salt are contained in the pressure-sensitive adhesive layer. This method preferably has: a step of preparing a mixture comprising the pressure-sensitive adhesive, the donepezil, the ascorbic acid, a metal salt or an ester thereof, and the metal metabisulfite salt; and a step of film-forming the pressure-sensitive adhesive layer by applying the mixture to the surface of the support.
摘要翻译： 通过抑制含有多奈哌齐的粘合剂的着色，实现了自然着色的外观。 [解决方案]在压敏粘合剂层中包含压敏粘合剂和多奈哌齐的粘合剂的制备方法中，具有支持体和粘合剂层的粘合剂的制备方法，抗坏血酸，金属盐或酯 并且在压敏粘合剂层中含有偏亚硫酸氢盐。 该方法优选具有：制备包含压敏粘合剂，多奈哌齐，抗坏血酸，金属盐或其酯和偏亚硫酸氢盐的混合物的步骤; 以及通过将所述混合物施加到所述载体的表面来成膜所述压敏粘合剂层的步骤。
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2.发明申请METHOD FOR SUPPRESSING DISCOLORATION OVER TIME OF ADHESIVE PREPARATION CONTAINING DONEPEZIL 审中-公开用于抑制含有二苯醚的胶粘剂制备时间的消除方法公开(公告)号：US20100048628A1
公开(公告)日：2010-02-25
申请号：US12517004
申请日：2007-11-30
申请人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
发明人： Sumiyo Nishi , Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Hitoshi Akemi , Satoko Washiro
IPC分类号： A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： [Object] Discoloration, over time, of a donepezil-containing adhesive preparation is suppressed.[Solution] At least one species of stabilizer selected from the group consisting of ascorbic acid, a metal salt or an ester thereof, isoascorbic acid or a metal salt thereof, ethylenediamine tetraacetic acid or a metal salt thereof, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, (±)-α-tocopherol, (±)-α-tocopherol acetate, rutin, hypophosphorous acid, a metal metabisulfite salt and a metal salt of hydroxymethanesulfinic acid, is blended in a pressure-sensitive adhesive layer containing a pressure-sensitive adhesive and donepezil.
摘要翻译： [目的]抑制多奈哌齐胶粘剂的变色，随着时间的推移。 [溶液]选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，（±）-α-生育酚，（±）-α-生育酚乙酸酯，芦丁，次磷酸，偏亚硫酸氢盐金属盐和羟基甲烷亚磺酸的金属盐混合在含有压敏粘合剂 和多奈哌齐。
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公开(公告)号：US20080131490A1
公开(公告)日：2008-06-05
申请号：US11987480
申请日：2007-11-30
申请人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Satoko Washiro , Hitoshi Akemi
发明人： Akinori Hanatani , Junichi Sekiya , Sachiko Terashi , Sumiyo Nishi , Satoko Washiro , Hitoshi Akemi
IPC分类号： A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K31/445 , A61K9/7061 , A61K31/375 , A61K33/04
摘要： A donepezil-containing patch preparation is provided whereby production of donepezil-related substances in the pressure-sensitive adhesive layer is suppressed. A stabilizer comprising at least one or more species selected from the group consisting of ascorbic acid, metal salts or esters thereof, isoascorbic acid or metal salts thereof, ethylenediamine tetraacetic acid or metal salts thereof, cysteine, acetylcysteine, 2-mercaptobenzimidazole, 3(2)-t-butyl-4-hydroxyanisole, 2,6-di-t-butyl-4-methylphenol, tetrakis[3-(3′,5′-di-t-butyl-4′-hydroxyphenyl)propionic acid]pentaerythritol, 3-mercapto-1,2-propanediol, tocopherol acetate, rutin, quercetin, hydroquinone, metal salts of hydroxymethanesulfinic acid, metal metabisulfite salts, metal sulfite salts and metal thiosulfate salts is blended in a donepezil-containing pressure-sensitive adhesive layer provided on at least one side of a support.
摘要翻译： 提供了含多奈哌齐的贴剂，抑制了压敏粘合剂层中多奈哌齐相关物质的产生。 包含至少一种或多种选自抗坏血酸，金属盐或其酯，异抗坏血酸或其金属盐，乙二胺四乙酸或其金属盐，半胱氨酸，乙酰半胱氨酸，2-巯基苯并咪唑，3（2 ）叔丁基-4-羟基苯甲醚，2,6-二叔丁基-4-甲基苯酚，四[3-（3'，5'-二叔丁基-4'-羟基苯基）丙酸]季戊四醇 ，3-巯基-1,2-丙二醇，生育酚乙酸酯，芦丁，槲皮素，氢醌，羟基甲烷亚磺酸的金属盐，偏亚硫酸氢盐，金属亚硫酸盐和金属硫代硫酸盐，配制在含有多奈哌齐的压敏粘合剂层中 在支架的至少一侧。
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公开(公告)号：US20100010043A1
公开(公告)日：2010-01-14
申请号：US12475249
申请日：2009-05-29
IPC分类号： A61K31/445 , C07D211/08
CPC分类号： A61K31/4465 , A61K9/7053 , A61K9/7061
摘要： The present invention provides a percutaneously absorbable preparation comprising 2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one and/or a hydrochloride thereof wherein the percuneously absorbable preoaration is able to administer to a patient such that Cmax per unit surface area of the percutaneously absorbable preparation is 0.025 to 0.5 ng/ml·cm2 in a plasma concentration profile.
摘要翻译： 本发明提供了包含2 - [（1-苄基哌啶-4-基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐的经皮吸收制剂，其中可以吸收的预制剂能够施用于 使得经皮吸收制剂的每单位表面积的C max在血浆浓度分布中为0.025至0.5ng / ml.cm 2。
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公开(公告)号：US20080131491A1
公开(公告)日：2008-06-05
申请号：US11987481
申请日：2007-11-30
申请人： Akinori Hanatani , Satoko Washiro , Hitoshi Akemi
发明人： Akinori Hanatani , Satoko Washiro , Hitoshi Akemi
IPC分类号： A61F13/02
CPC分类号： A61K9/7061 , A61F2013/00646 , A61K31/445
摘要： The present invention provides a percutaneously absorbable preparation for percutaneous absorption of donepezil or its hydrochloride which is stable and resistant to loss of cohesiveness of the pressure-sensitive adhesive layer while attached and resistant to adhesive transfer due to cohesive failure during removal by peeling. The percutaneously absorbable preparation comprises 2-[(1-benzyl-4-piperidinyl)methyl]-5,6-dimethoxyindan-1-on and/or its hydrochloride and a metal chloride in a pressure-sensitive adhesive layer which has been crosslinked.
摘要翻译： 本发明提供一种用于经皮吸收多奈哌齐或其盐酸盐的经皮吸收制剂，其在附着时耐压粘合剂层的稳定性和耐粘附性，并且由于通过剥离去除期间的内聚力破坏而抵抗粘合剂转移。 经皮吸收制剂包含2 - [（1-苄基-4-哌啶基）甲基] -5,6-二甲氧基茚满-1-酮和/或其盐酸盐和已经交联的压敏粘合剂层中的金属氯化物。
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公开(公告)号：US09040077B2
公开(公告)日：2015-05-26
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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公开(公告)号：US20100203108A1
公开(公告)日：2010-08-12
申请号：US12656700
申请日：2010-02-12
CPC分类号： A61K9/703 , A61F2013/00651 , A61K9/7061
摘要： The present invention provides to a patch and a patch preparation having low stretchability, which can be continuously adhered to the skin for a long time without undesirable detachment and marked falling off from the skin due to various factors during adhesion, and specifically provides a low stretchable patch and a patch preparation containing a support and an adhesive layer formed on one surface of the support, wherein a ratio P of the total length W (mm) of curved sections of a planar outer shape of the patch to the total length S (mm) of straight-line sections of the planar outer shape of the patch (W/S) is not more than 1.22, and, when the curved sections are approximated by a circular arc, the radius R (mm) of the circular arc is not less than 0.5 mm.
摘要翻译： 本发明提供一种具有低拉伸性的贴剂和贴片制剂，其可以在粘合期间由于各种因素而长时间连续地粘附到皮肤上而没有不希望的分离并且从皮肤上显着脱落，并且具体地提供了低伸缩性 贴片和贴片制剂，其包含支撑体和形成在支撑体的一个表面上的粘合剂层，其中贴片平面外形的弯曲部分的总长度W（mm）与总长度S（mm）之比P （W / S）的平面外形的直线部分的面积不大于1.22，并且当弯曲部分被圆弧近似时，圆弧的半径R（mm）不是 小于0.5毫米。
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公开(公告)号：US08033395B2
公开(公告)日：2011-10-11
申请号：US12314564
申请日：2008-12-12
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在 补丁1。
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公开(公告)号：US20110056863A1
公开(公告)日：2011-03-10
申请号：US12990818
申请日：2009-05-26
IPC分类号： B65D85/00 , A61K9/70 , A61K31/445 , A61P25/28
CPC分类号： A61K9/7061 , A61K31/4465 , B65D81/24
摘要： [Object] An adhesive preparation containing donepezil is provided in which adhesive layer discoloration over time is inhibited.[Solution] The adhesive preparation containing donepezil has an adhesive layer containing donepezil and an acrylic adhesive on at least one side of a support, and a water content of the adhesive layer is 1000 ppm or more. The water content of the adhesive layer is preferably 8000 ppm or less and more preferably 7000 ppm or less.
摘要翻译： 提供了含有多奈哌齐的粘合剂，其中粘合剂层随着时间的变色被抑制。 [解决方案]含有多奈哌齐的粘合剂在载体的至少一侧上具有含有多奈哌齐和丙烯酸类粘合剂的粘合剂层，粘合剂层的含水量为1000ppm以上。 粘合剂层的含水量优选为8000ppm以下，更优选为7000ppm以下。
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公开(公告)号：US20090166229A1
公开(公告)日：2009-07-02
申请号：US12314564
申请日：2008-12-12
摘要： The main object of the present invention is to provide a patch package structure including a patch containing a physiologically active ingredient and a package housing the patch, which is capable of stably retaining the physiologically active ingredient in the patch during preservation. This object can be achieved by employing the following constitution.To be specific, the present invention is a patch package structure including a patch 1 having an adhesive layer containing an organic liquid component, and a packaging member 51 housing the patch, wherein the packaging member 51 includes a first package 11, the first package 11 including an acrylonitrile resin layer 12, a moisture-absorbing layer 13 formed on the acrylonitrile resin layer 12, and a moisture impermeable layer 14 formed on the moisture-absorbing layer 13, and the acrylonitrile resin layer 12 is provided on the proximal side of the patch 1.
摘要翻译： 本发明的主要目的是提供一种贴片包装结构，其包括含有生理活性成分的贴剂和容纳该贴剂的包装，其能够在保存期间稳定地保留贴剂中的生理活性成分。 该目的可以通过采用以下结构来实现。 具体而言，本发明是一种贴片包装结构，其包括具有含有有机液体成分的粘合剂层的贴片1和容纳该贴片的包装部件51，其中，包装部件51包括第一包装体11，第一包装体11 包括丙烯腈树脂层12，形成在丙烯腈树脂层12上的吸湿层13和形成在吸湿层13上的不透水层14和丙烯腈树脂层12设置在 补丁1。
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