发明申请
- 专利标题: MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID
- 专利标题(中): 3-羟基丁酸的微生物生产
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申请号: US12303161申请日: 2007-06-01
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公开(公告)号: US20100068773A1公开(公告)日: 2010-03-18
- 发明人: Achim Marx , Markus Poetter , Stefen Buchholz , Alexander May , Hermann Siegert , Georg Fuchs , Birgit Alber , Lothar Eggeling
- 申请人: Achim Marx , Markus Poetter , Stefen Buchholz , Alexander May , Hermann Siegert , Georg Fuchs , Birgit Alber , Lothar Eggeling
- 申请人地址: DE Darmstadt
- 专利权人: Evonik Roehm GmbH
- 当前专利权人: Evonik Roehm GmbH
- 当前专利权人地址: DE Darmstadt
- 优先权: DE102006025821.5 20060602
- 国际申请: PCT/EP2007/055394 WO 20070601
- 主分类号: C12P7/62
- IPC分类号: C12P7/62 ; C12N1/21 ; C12P7/42 ; C07H21/04 ; C12N15/74 ; C07K14/00
摘要:
The present invention relates to a cell which has been modified in comparison with its wild type in such a way that it is capable of forming more, by comparison with its wild, 3-hydroxyisobutyric acid or poly-hydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate-semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method of generating a genetically modified cell, to the genetically modified cell obtainable by these methods, to a method of producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method of producing methacrylic acid or methacrylic esters, and to a method of producing polymethacrylic acid or polymethacrylic esters. The present invention furthermore relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.
公开/授权文献
- US3081103A Chuck especially for lathes 公开/授权日:1963-03-12