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    PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS
    1.
    发明申请
    PROCESS FOR PREPARING METHACRYLIC ACID OR METHACRYLIC ESTERS 有权
    制备甲基丙烯酸或甲基丙烯酸酯的方法

    公开(公告)号：US20100291644A1

    公开(公告)日：2010-11-18

    申请号：US12602593

    申请日：2008-05-30

    Applicant: Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    Inventor： Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    IPC: C12P7/62 ,  C12P7/40 ,  C12P7/44

    CPC classification number: C12P7/42 ,  C08F120/06 ,  C08F120/10 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/88 ,  C12P7/40 ,  C12P7/52 ,  C12P7/625 ,  C12Y102/04004 ,  C12Y103/99012 ,  C12Y206/01042 ,  C12Y301/02004 ,  C12Y402/01017

    Abstract: The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid, IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid. The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.

    Abstract translation: 本发明涉及一种制备甲基丙烯酸或甲基丙烯酸酯的方法，其包括以下工艺步骤：IA）通过包括以下步骤的方法制备3-羟基异丁酸，所述方法包括将经遗传修饰的细胞与其 野生型，使得其能够形成更多的3-羟基异丁酸或与其野生型相比基于3-羟基异丁酸的聚羟基链烷酸酯与营养培养基接触，所述营养培养基包含作为碳源的碳水化合物，甘油，碳 二氧化物，甲醇，L-缬氨酸或L-谷氨酸盐，其中3-羟基异丁酸或基于3-羟基异丁酸的聚羟基链烷酸酯由碳源形成的条件下，如果合适，则从营养培养基中分离出3-羟基异丁酸， 如果适当，中和3-羟基异丁酸，IB）3-羟基异丁酸脱水形成甲基丙烯酸 酸，并且在适当的情况下酯化甲基丙烯酸。 本发明还涉及一种制备聚甲基丙烯酸或聚甲基丙烯酸酯的方法。

    Process for preparing methacrylic acid or methacrylic esters
    4.
    发明授权
    Process for preparing methacrylic acid or methacrylic esters 有权
    制备甲基丙烯酸或甲基丙烯酸酯的方法

    公开(公告)号：US09234218B2

    公开(公告)日：2016-01-12

    申请号：US12602593

    申请日：2008-05-30

    Applicant: Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    Inventor： Achim Marx ,  Markus Poetter ,  Stefan Buchholz ,  Alexander May ,  Hermann Siegert ,  Birgit Alber ,  Georg Fuchs ,  Lothar Eggeling

    IPC: C12P7/42 ,  C12P7/52 ,  C12N9/02 ,  C12P7/40 ,  C12P7/62 ,  C08F120/06 ,  C08F120/10 ,  C12N9/10 ,  C12N9/16 ,  C12N9/88

    CPC classification number: C12P7/42 ,  C08F120/06 ,  C08F120/10 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1096 ,  C12N9/16 ,  C12N9/88 ,  C12P7/40 ,  C12P7/52 ,  C12P7/625 ,  C12Y102/04004 ,  C12Y103/99012 ,  C12Y206/01042 ,  C12Y301/02004 ,  C12Y402/01017

    Abstract: The present invention relates to a process for the preparation of methacrylic acid or methacrylic esters, comprising the process steps of IA) preparation of 3-hydroxyisobutyric acid by a process comprising the process step of bringing a cell which has been genetically modified in comparison with its wild type in such a way that it is capable of forming more 3-hydroxyisobutyric acid, or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid in comparison with its wild type, into contact with a nutrient medium comprising, as carbon source, carbohydrates, glycerol, carbon dioxide, methanol, L-valine or L-glutamate under conditions under which 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid are formed from the carbon source, if appropriate, isolation of the 3-hydroxyisobutyric acid from the nutrient medium and also, if appropriate, neutralization of the 3-hydroxyisobutyric acid, IB) dehydration of the 3-hydroxyisobutyric acid with formation of methacrylic acid and also, where appropriate, esterification methacrylic acid. The invention also relates to a process for the preparation of polymethacrylic acid or polymethacrylic esters.

    Abstract translation: 本发明涉及一种制备甲基丙烯酸或甲基丙烯酸酯的方法，其包括以下工艺步骤：IA）通过包括以下步骤的方法制备3-羟基异丁酸，所述方法包括将经遗传修饰的细胞与其 野生型，使得其能够形成更多的3-羟基异丁酸或与其野生型相比基于3-羟基异丁酸的聚羟基链烷酸酯与营养培养基接触，所述营养培养基包含作为碳源的碳水化合物，甘油，碳 二氧化物，甲醇，L-缬氨酸或L-谷氨酸盐，其中3-羟基异丁酸或基于3-羟基异丁酸的聚羟基链烷酸酯由碳源形成的条件下，如果合适，则从营养培养基中分离出3-羟基异丁酸， 如果适当，中和3-羟基异丁酸，IB）3-羟基异丁酸脱水形成甲基丙烯酸 酸，并且在适当的情况下酯化甲基丙烯酸。 本发明还涉及一种制备聚甲基丙烯酸或聚甲基丙烯酸酯的方法。

    ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF
    5.
    发明申请
    ENZYME FOR THE PRODUCTION OF METHYLMALONYL-COENZYME A OR ETHYLMALONYL-COENZYME A AND USE THEREOF 审中-公开
    用于生产甲基亚甲基二甲基丙烯酸酯或其乙烯基 - 苯甲醚的酶及其用途

    公开(公告)号：US20100190224A1

    公开(公告)日：2010-07-29

    申请号：US12593090

    申请日：2008-03-27

    Applicant: Markus Poetter ,  Achim Marx ,  Georg Fuchs ,  Birgit Alber ,  Tobias Juergen Erb

    Inventor： Markus Poetter ,  Achim Marx ,  Georg Fuchs ,  Birgit Alber ,  Tobias Juergen Erb

    IPC: C12P7/42 ,  C12N15/74 ,  C12N9/00 ,  C12N1/21 ,  C12N15/63 ,  C07H21/04

    CPC classification number: C12P7/52 ,  C12N9/506 ,  C12P7/42

    Abstract: The present invention relates to an isolated DNA, which is selected from the following sequences: a) a sequence according to SEQ ID No. 01, b) an intron-free sequence that is derived from a sequence according to a) and encodes the same protein or peptide as the sequence according to SEQ ID No. 01, c) a sequence that encodes a protein or peptide, which comprises the amino acid sequence according to SEQ ID No. 02, d) a sequence that is at least 80% identical to a sequence according to a) to c), e) a sequence that hybridizes with the antisense strand of a sequence according to one of the groups a) to d) or would hybridize taking into account degeneration of the genetic code, f) a derivative of a sequence according to one of the groups a) to e) obtained by substitution, addition, inversion and/or deletion of one or more bases, g) a sequence that corresponds to SEQ ID No. 01 within the degeneration of the genetic code, h) a sequence with neutral sense mutations of SEQ ID No. 01, and i) a sequence complementary to a sequence according to one of the groups a) to h). The invention further relates to a vector, the use of this vector for transformation of a cell, a transformed cell, a polypeptide, cells genetically engineered relative to their wild type, a method of production of a genetically engineered cell, the genetically engineered cell obtainable by this method, the use of this cell and a method of production of 3-hydroxyisobutyric acid or of a derivative thereof.

    Abstract translation: 本发明涉及分离的DNA，其选自以下序列：a）根据SEQ ID No 01的序列，b）源自根据a）的序列的内含子序列，并编码它们 蛋白质或肽，其为编码蛋白质或肽的序列，其包含根据SEQ ID No.22的氨基酸序列，d）至少80％相同的序列 根据a）至c）的序列，e）与根据a）至d）中的一个组的序列的反义链杂交的序列或将考虑到遗传密码的变性而杂交，f）a 根据通过一个或多个碱基的取代，添加，倒位和/或缺失得到的a）至e）中的一个序列的序列的衍生物，g）在遗传变性中对应于SEQ ID No 01的序列 代码，h）具有SEQ ID No 01的中性有义突变的序列，和i） 与根据a）至h）中的一个组合的序列互补的序列。 本发明进一步涉及载体，该载体用于转化细胞，转化细胞，多肽，相对于其野生型基因工程改造的细胞，遗传工程细胞的生产方法，可获得的遗传工程改造的细胞 通过该方法，可以使用该细胞和3-羟基异丁酸或其衍生物的制造方法。

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