Invention Application
US20100068802A1 NOVEL HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS AS BIOMARKERS AND THERAPEUTIC TARGETS
有权
作为生物标志物和治疗目标的新型人类受体受体替代品种变异
- Patent Title: NOVEL HUMAN ANDROGEN RECEPTOR ALTERNATIVE SPLICE VARIANTS AS BIOMARKERS AND THERAPEUTIC TARGETS
- Patent Title (中): 作为生物标志物和治疗目标的新型人类受体受体替代品种变异
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Application No.: US12562031Application Date: 2009-09-17
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Publication No.: US20100068802A1Publication Date: 2010-03-18
- Inventor: Yun Qiu , Zhiyong Guo , Xi Yang
- Applicant: Yun Qiu , Zhiyong Guo , Xi Yang
- Applicant Address: US MD Baltimore
- Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee: UNIVERSITY OF MARYLAND, BALTIMORE
- Current Assignee Address: US MD Baltimore
- Main IPC: C12N5/00
- IPC: C12N5/00 ; C07H21/00 ; C07K2/00
Abstract:
The present invention relates to novel androgen receptor splice variants (AR3, AR4, AR4b, AR5 and AR8) and variants and fragments thereof which have a role in the progression of androgen independent prostate cancer. The invention further relates to compositions and methods which can be used to identify and treat prostate cancer based on these novel androgen receptor splice variants, as well as methods for screening agents which modulate the activity and/or expression of the androgen receptor splice variants. Vectors, host cells and recombinant methods for producing the same and transgenic animals are also provided.
Public/Granted literature
- US08133724B2 Human androgen receptor alternative splice variants as biomarkers and therapeutic targets Public/Granted day:2012-03-13
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