发明申请
- 专利标题： VACCINE NEBULIZERS
- 专利标题（中）： 疫苗接种者
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申请号： US11993520申请日： 2006-06-27
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公开(公告)号： US20100074911A1公开(公告)日： 2010-03-25
- 发明人: Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
- 申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
- 优先权： EP05013805.6 20050627
- 国际申请： PCT/EP06/06168 WO 20060627
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; A61M11/00
摘要：
The invention provides a method of selecting or optimising a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. The additional preferred features are disclosed for the selection of nebulisers for use in mass vaccination programs.Nebulisers identified by the methods of the invention are also claimed.
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