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公开(公告)号：US20130032140A1
公开(公告)日：2013-02-07
申请号：US13650535
申请日：2012-10-12
申请人： Felicity Cutts , Jorge FERNANDEZ DE CASTRO , John V. BENNETT , Beth LAUBE , Clyde WITHAM , Ana Maria HENAO-RESTREPO , Bernard COHEN , David BROWN , John DENNIS
发明人： Felicity Cutts , Jorge FERNANDEZ DE CASTRO , John V. BENNETT , Beth LAUBE , Clyde WITHAM , Ana Maria HENAO-RESTREPO , Bernard COHEN , David BROWN , John DENNIS
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. Nebulisers identified by the methods of the invention are also claimed.
摘要翻译： 本发明提供了一种选择用于递送疫苗的雾化器装置的方法，包括选择能够产生具有以下颗粒液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm（ii ）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5至8.0μm的平均质量空气动力学直径（MMAD）这允许例如以前可商购的雾化器 用于药物输送，用于疫苗递送。 这大大降低了识别合适的雾化器所需的工作。 通过本发明的方法识别的雾化器也被要求保护。
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公开(公告)号：US08887713B2
公开(公告)日：2014-11-18
申请号：US13650535
申请日：2012-10-12
申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
发明人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting a nebulizer device to be used to deliver a vaccine comprising selecting a nebulizer capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulizers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulizers. Nebulizers identified by the methods of the invention are also claimed.
摘要翻译： 本发明提供了一种选择用于递送疫苗的喷雾器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm（ii ）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许例如以前可商购的喷雾器 用于药物输送，用于疫苗递送。 这大大降低了识别合适的喷雾器所需的工作。 通过本发明的方法识别的喷雾器也被要求保护。
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公开(公告)号：US20100074911A1
公开(公告)日：2010-03-25
申请号：US11993520
申请日：2006-06-27
申请人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
发明人： Felicity Cutts , Jorge Fernandez De Castro , John V. Bennett , Beth Laube , Clyde Witham , Ana Maria Henao-Restrepo , Bernard Cohen , David Brown , John Dennis
CPC分类号： A61M11/02 , A61M11/005 , A61M15/0086 , A61M16/0045 , A61M16/0666 , A61M16/1055 , A61M16/107 , A61M2202/30
摘要： The invention provides a method of selecting or optimising a nebuliser device to be used to deliver a vaccine comprising selecting a nebuliser capable of producing a plurality of vaccine particles having the following particle droplet size distribution: (i) Dv10: 2.0+/−0.2 μm (ii) Dv50: 5.0+/−0.5 μm (iii) Dv90: 10.0+/−1.0 μm (iv) a mean mass aerodynamic diameter (MMAD) of 4.5 to 8.0 μm This allows the selection of, for example, commercially available nebulisers, previously used for drug delivery, for vaccine delivery. This considerably reduces the work required to identify suitable nebulisers. The additional preferred features are disclosed for the selection of nebulisers for use in mass vaccination programs.Nebulisers identified by the methods of the invention are also claimed.
摘要翻译： 本发明提供一种选择或优化用于递送疫苗的雾化器装置的方法，包括选择能够产生具有以下粒子液滴尺寸分布的多个疫苗颗粒的雾化器：（i）Dv10：2.0 +/-0.2μm （ii）Dv50：5.0 +/-0.5μm（iii）Dv90：10.0 +/-1.0μm（iv）4.5-8.0μm的平均质量空气动力学直径（MMAD）这允许选择例如市售的雾化器 ，以前用于药物递送，用于疫苗递送。 这大大降低了识别合适的雾化器所需的工作。 公开了额外的优选特征，用于选择用于大规模疫苗接种程序中的雾化器。 通过本发明的方法识别的雾化器也被要求保护。
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