发明申请
- 专利标题： RADIOLABELLED INHIBITORS OF THE GLYCINE 1 TRANSPORTER
- 专利标题（中）： 甘油1转运蛋白的放射性抑制剂
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申请号： US12607111申请日： 2009-10-28
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公开(公告)号： US20100111862A1公开(公告)日： 2010-05-06
- 发明人: Daniela Alberati , Edilio Maurizio Borroni , Thomas Hartung , Roger Norcross , Emmanuel Pinard
- 申请人： Daniela Alberati , Edilio Maurizio Borroni , Thomas Hartung , Roger Norcross , Emmanuel Pinard
- 优先权： EP08168229.6 20081104
- 主分类号： A61K51/04
- IPC分类号： A61K51/04 ; C07D209/02 ; A61P25/18
摘要：
The present invention relates to novel radiolabelled inhibitors of formula I for the Glycine 1 transporter (GlyT1), useful for the labelling and diagnostic imaging of the glycine 1 transporter functionality. whereinR1 is isopropoxy or 2,2,2-trifluoro-1-methyl-ethoxy; andR2 is a radiolabelled group CH3, wherein the radionuclide is 3H or 11C. The radiolabelled compounds of formula I may be used as PET (Positron Emission Tomography) radiotracer for the labelling and diagnostic molecular imaging of the glycine 1 transporter functionality.
公开/授权文献
- US08153679B2 Radiolabelled inhibitors of the glycine 1 transporter 公开/授权日：2012-04-10
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