发明申请
US20100113801A1 Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
有权
制备5-联苯-4-氨基-2-甲基戊酸的方法
- 专利标题： Process for preparing 5-biphenyl-4-amino-2-methyl pentanoic acid
- 专利标题（中）： 制备5-联苯-4-氨基-2-甲基戊酸的方法
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申请号： US12522767申请日： 2008-01-10
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公开(公告)号： US20100113801A1公开(公告)日： 2010-05-06
- 发明人: David Hook , Thomas Ruch , Bernhard Riss , Bernhard Wietfeld , Gottfried Sedelmeier , Matthias Napp , Markus Bänziger , Steven Hawker , Lech Ciszewski , Liladhar M. Waykole
- 申请人： David Hook , Thomas Ruch , Bernhard Riss , Bernhard Wietfeld , Gottfried Sedelmeier , Matthias Napp , Markus Bänziger , Steven Hawker , Lech Ciszewski , Liladhar M. Waykole
- 优先权： EP07100451.9 20070112
- 国际申请： PCT/EP2008/000142 WO 20080110
- 主分类号： C07D207/18
- IPC分类号： C07D207/18 ; C07F7/10 ; C07D207/22 ; C07D207/20
摘要：
The present invention relates to pyrrolidin-2-ones according to the formula (1), or salts thereof, wherein R1 is hydrogen or a nitrogen protecting group, methods for their preparation and their use in the preparation of NEP-inhibitors, particularly in the preparation of N-(3-carboxyl-1-oxopropyl)-(4S)-(p-phenylphenylmethyl)-4-amino-(2R)-methyl butanoic acid ethyl ester or salt thereof.
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