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    Salts and crystall forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile
    9.
    发明授权
    Salts and crystall forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile 有权
    2-甲基-2- [4-（3-甲基-2-氧代-8-喹啉-3-基-2,3-二氢 - 咪唑并[4,5-c]喹啉-1-基）的盐和结晶形式 ） - 苯基] - 丙腈

    公开(公告)号：US08436177B2

    公开(公告)日：2013-05-07

    申请号：US12514976

    申请日：2007-11-16

    申请人： Frank Stowasser ,  Markus Bänziger ,  Sudhakar Devidasrao Garad

    发明人： Frank Stowasser ,  Markus Bänziger ,  Sudhakar Devidasrao Garad

    IPC分类号： C07D471/06 ,  C07D471/16 ,  A61K31/437

    CPC分类号： C07D471/04 ,  C07C309/30

    摘要： The invention relates to particular crystalline forms of 2-methyl-2-[4-(3-methyl-2-oxo-8-quinolin-3-yl-2,3-dihydro-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile, its hydrates and solvates, its salts and hydrates and solvates of its salts, certain processes for their preparation, pharmaceutical compositions containing these crystalline forms, and their use in diagnostic methods or, preferably, for the therapeutic treatment of warm-blooded animals, especially humans, and their use as an intermediate or for the preparation of pharmaceutical preparations for use in diagnostic methods or, preferably, for the therapeutic treatment of warm-blooded animals, especially humans.

    摘要翻译： 本发明涉及2-甲基-2- [4-（3-甲基-2-氧代-8-喹啉-3-基-2,3-二氢 - 咪唑并[4,5-c]喹啉-2-基） 1-基） - 苯基] - 丙腈，其水合物和溶剂化物，其盐和水合物及其盐的溶剂合物，其制备方法，含有这些结晶形式的药物组合物及其在诊断方法中的用途，或优选用于 温血动物，特别是人的治疗性治疗，以及它们作为中间体的用途，或用于制备用于诊断方法的药物制剂，或优选用于治疗温血动物，特别是人的治疗。