发明申请
- 专利标题： MONOCLONAL ANTIBODIES THAT NEUTRALIZE ANTHRAX TOXINS
- 专利标题（中）： 中和毒素的单克隆抗体
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申请号： US12528427申请日： 2008-02-21
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公开(公告)号： US20100119520A1公开(公告)日： 2010-05-13
- 发明人: Zhaochun Chen , Robert H. Purcell , Suzanne U. Emerson , Stephen H. Leppla , Mahtab Moayeri
- 申请人： Zhaochun Chen , Robert H. Purcell , Suzanne U. Emerson , Stephen H. Leppla , Mahtab Moayeri
- 申请人地址： US MD Rockville
- 专利权人： THE UNITED STATES OF AMERICA, as represented by TH
- 当前专利权人： THE UNITED STATES OF AMERICA, as represented by TH
- 当前专利权人地址： US MD Rockville
- 国际申请： PCT/US2008/054609 WO 20080221
- 主分类号： A61K39/40
- IPC分类号： A61K39/40 ; C07K16/12 ; C07H21/04 ; C12N5/00 ; G01N33/53 ; G01N33/566
摘要：
The present invention relates to monoclonal antibodies that bind or neutralize anthrax lethal factor (LF), edema factor (EF), and/or protective antigen (PA). The invention provides such antibodies, fragments of such antibodies retaining anthrax toxin-binding ability, fully human or humanized antibodies retaining anthrax toxin-binding ability, and pharmaceutical compositions including such antibodies. The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention.
公开/授权文献
- US08071100B2 Monoclonal antibodies that neutralize anthrax toxins 公开/授权日：2011-12-06
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