发明申请
- 专利标题: ANTIBODIES AGAINST HUMAN INTERLEUKIN-13 AND USES THEREFOR
- 专利标题(中): 抗体人类抗体13及其用途
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申请号: US12575896申请日: 2009-10-08
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公开(公告)号: US20100129360A1公开(公告)日: 2010-05-27
- 发明人: Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
- 申请人: Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
- 申请人地址: US NJ Madison
- 专利权人: WYETH LLC
- 当前专利权人: WYETH LLC
- 当前专利权人地址: US NJ Madison
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/24 ; C07K16/18 ; C07H21/00 ; C12N5/10 ; C12P21/00 ; G01N33/543 ; A61P37/02
摘要:
This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
公开/授权文献
- US08221752B2 Antibodies against human interleukin-13 and uses therefor 公开/授权日:2012-07-17