-
公开(公告)号：US07943342B2
公开(公告)日：2011-05-17
申请号：US12358111
申请日：2009-01-22
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
-
公开(公告)号：US08221752B2
公开(公告)日：2012-07-17
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白介素13（IL-13），特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
-
公开(公告)号：US20110262435A1
公开(公告)日：2011-10-27
申请号：US13098668
申请日：2011-05-02
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号： A61K39/395 , A61P11/00 , A61P1/00 , A61P35/00 , A61P37/02 , A61P29/00 , A61P11/06 , A61P31/12
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
-
公开(公告)号：US20090274705A1
公开(公告)日：2009-11-05
申请号：US12358111
申请日：2009-01-22
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
-
公开(公告)号：US20100129360A1
公开(公告)日：2010-05-27
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395 , C07K16/24 , C07K16/18 , C07H21/00 , C12N5/10 , C12P21/00 , G01N33/543 , A61P37/02
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
-
公开(公告)号：US07501121B2
公开(公告)日：2009-03-10
申请号：US11155843
申请日：2005-06-17
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
-
7.发明授权Antibodies against human interleukin-13 and pharmaceutical compositions thereof 失效针对人白细胞介素-13的抗体及其药物组合物公开(公告)号：US07615213B2
公开(公告)日：2009-11-10
申请号：US11149309
申请日：2005-06-09
申请人： Marion T. Kasaian , Lioudmila Tchistiakova , Geertruida M. Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Tchistiakova , Geertruida M. Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段，以及它们在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.016 秒)
