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公开(公告)号：US07943342B2
公开(公告)日：2011-05-17
申请号：US12358111
申请日：2009-01-22
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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2.发明授权Antibodies against human interleukin-13 and pharmaceutical compositions thereof 失效针对人白细胞介素-13的抗体及其药物组合物公开(公告)号：US07615213B2
公开(公告)日：2009-11-10
申请号：US11149309
申请日：2005-06-09
申请人： Marion T. Kasaian , Lioudmila Tchistiakova , Geertruida M. Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Tchistiakova , Geertruida M. Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段，以及它们在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
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公开(公告)号：US20080241098A1
公开(公告)日：2008-10-02
申请号：US11947425
申请日：2007-11-29
申请人： Deborah A. Young , Mary Collins , Kyriaki Dunussi-Joannopoulos , Richard Michael O'Hara , Marion T. Kasaian , Matthew J. Whitters
发明人： Deborah A. Young , Mary Collins , Kyriaki Dunussi-Joannopoulos , Richard Michael O'Hara , Marion T. Kasaian , Matthew J. Whitters
IPC分类号： A61K38/20 , A61K39/395 , A61K39/44 , C07K16/46 , C12N15/63 , C12N5/06 , C12P21/00 , A61P41/00
CPC分类号： C07K16/2866 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/0368 , A61K38/1793 , A61K49/0008 , A61K2039/505 , C07K14/7155 , C07K2319/30 , G01N33/6869 , G01N33/6893 , G01N2500/02 , G01N2800/245
摘要： Methods and compositions for inhibiting interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed. IL-21/IL-21R antagonists can be used to induce immune suppression in vivo, e.g., for treating, ameliorating or preventing autoimmune or inflammatory disorders, including, e.g., inflammatory bowel disease (IBD), rheumatoid arthritis (RA), transplant/graft rejection, psoriasis, asthma, fibrosis, and systemic lupus erythematosus (SLE).
摘要翻译： 使用IL-21或IL-21受体（“IL-21R”或“MU-1”）拮抗剂抑制白细胞介素-21（IL-21）/ IL-21受体（MU-1）活性的方法和组合物 披露 IL-21 / IL-21R拮抗剂可用于诱导体内的免疫抑制，例如用于治疗，改善或预防自身免疫性或炎症性疾病，包括例如炎症性肠病（IBD），类风湿性关节炎（RA），移植/ 移植物排斥，牛皮癣，哮喘，纤维化和系统性红斑狼疮（SLE）。
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4.发明授权公开(公告)号：US07198789B2
公开(公告)日：2007-04-03
申请号：US10264634
申请日：2002-10-04
申请人： Laura Carter , Beatriz Carreno , Leslie D. Lowe , Matthew J. Whitters , Kyri Dunussi , Mary Collins , Margery Ma , Deborah A. Young , JoAnn S. Witek , Glenn Larsen , Marion T. Kasaian , Debra D. Donaldson , Michelle Unger
发明人： Laura Carter , Beatriz Carreno , Leslie D. Lowe , Matthew J. Whitters , Kyri Dunussi , Mary Collins , Margery Ma , Deborah A. Young , JoAnn S. Witek , Glenn Larsen , Marion T. Kasaian , Debra D. Donaldson , Michelle Unger
IPC分类号： A61K39/00 , A61K39/395 , A61K38/17
CPC分类号： C07K14/715 , A61K38/1793 , A61K38/20 , C07K2319/30
摘要： Methods and compositions for modulating interleukin-21 (IL-21)/IL-21 receptor (MU-1) activity using agonists or antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed. IL-21/IL-21R antagonists can be used to induce immune suppression in vivo, e.g., for treating or preventing immune cell-associated pathologies (e.g., pathologies associated with aberrant activity of one or more of mature T cells (mature CD8+, mature CD4+ T cells), mature NK cells, B cells, macrophages and megakaryocytes, including transplant rejection and autoimmune disorders). IL-21/IL-21R agonists can be used by themselves or in combination with an antigen, e.g., as an adjuvant (e.g., a vaccine adjuvant), to up-regulate an immune response in vivo, e.g., for example, for use in treating cancer and infectious disorders.
摘要翻译： 使用IL-21或IL-21受体（“IL-21R”或“MU-1”）的激动剂或拮抗剂调节白细胞介素-21（IL-21）/ IL-21受体（MU-1）活性的方法和组合物 ，被披露。 IL-21 / IL-21R拮抗剂可用于在体内诱导免疫抑制，例如用于治疗或预防免疫细胞相关病理学（例如，与一种或多种成熟T细胞的异常活性相关的病理学（成熟CD8 +，成熟 CD4 + T细胞），成熟NK细胞，B细胞，巨噬细胞和巨核细胞，包括移植排斥反应和自身免疫性疾病。 IL-21 / IL-21R激动剂可以自身使用或与抗原组合使用，例如作为佐剂（例如，疫苗佐剂），以在体内上调免疫应答，例如使用 在治疗癌症和感染性疾病。
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公开(公告)号：US20100129360A1
公开(公告)日：2010-05-27
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395 , C07K16/24 , C07K16/18 , C07H21/00 , C12N5/10 , C12P21/00 , G01N33/543 , A61P37/02
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白细胞介素-13（IL-13）特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
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6.发明申请Methods and compositions for treating and monitoring treatment of IL-13-associated disorders 审中-公开用于治疗和监测IL-13相关疾病治疗的方法和组合物公开(公告)号：US20090098142A1
公开(公告)日：2009-04-16
申请号：US12001637
申请日：2007-12-11
IPC分类号： A61K39/395 , G01N33/53 , A61P37/06
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Methods and compositions for treating and/or monitoring treatment of IL-13-associated disorders or conditions are disclosed.
摘要翻译： 公开了用于治疗和/或监测治疗IL-13相关疾病或病症的方法和组合物。
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公开(公告)号：US07501121B2
公开(公告)日：2009-03-10
申请号：US11155843
申请日：2005-06-17
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号： A61K39/395 , C07K16/24
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US08221752B2
公开(公告)日：2012-07-17
申请号：US12575896
申请日：2009-10-08
申请人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
发明人： Marion T. Kasaian , Lioudmila Gennadievna Tchistiakova , Geertruida Machteld Veldman , Kimberly Ann Marquette , Xiang-Yang Tan , Debra D. Donaldson , Laura Long Lin , Tania Shane , Amy Sze Pui Tam , Eric Feyfant , Nancy L. Wood , Lori J. Fitz , Angela M. Widom , Kevin D. Parris , Samuel J. Goldman , Jose W. Saldanha
IPC分类号： A61K39/395
CPC分类号： C07K16/244 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/73 , C07K2317/732 , C07K2317/76 , C07K2317/92
摘要： This application relates to antibodies, e.g., humanized antibodies, and antigen-binding fragments thereof, that bind to interleukin-13 (IL-13), in particular, human IL-13, and their uses in regulating immune responses mediated by IL-13. The antibodies disclosed herein are useful in diagnosing, preventing, and/or treating a subject, e.g., a human patient, one or more IL-13-associated disorders, e.g., respiratory disorders (e.g., asthma); atopic disorders (e.g., allergic rhinitis); inflammatory and/or autoimmune conditions of the skin (e.g., atopic dermatitis), and gastrointestinal organs (e.g., inflammatory bowel diseases (IBD)), as well as fibrotic and cancerous disorders.
摘要翻译： 本申请涉及结合白介素13（IL-13），特别是人IL-13的抗体，例如人源化抗体及其抗原结合片段及其在调节由IL-13介导的免疫应答中的用途 。 本文公开的抗体可用于诊断，预防和/或治疗受试者，例如人类患者，一种或多种IL-13相关疾病，例如呼吸系统疾病（例如哮喘）; 特应性疾病（如过敏性鼻炎）; 皮肤的炎症和/或自身免疫病症（例如特应性皮炎）和胃肠器官（例如炎性肠病（IBD））以及纤维化和癌性疾病。
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公开(公告)号：US20110262435A1
公开(公告)日：2011-10-27
申请号：US13098668
申请日：2011-05-02
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
IPC分类号： A61K39/395 , A61P11/00 , A61P1/00 , A61P35/00 , A61P37/02 , A61P29/00 , A61P11/06 , A61P31/12
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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公开(公告)号：US20090274705A1
公开(公告)日：2009-11-05
申请号：US12358111
申请日：2009-01-22
申请人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
发明人： Lioudmila Tchistiakova , Marion T. Kasaian , Debra D. Donaldson , Xiang-Yang Tan , Davinder Gill , Macy X. Jin , Bruce Jacobson , Samuel J. Goldman , John Knopf , Angela M. Widom
CPC分类号： C07K16/244 , A61K2039/505 , C07K2317/24 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/71 , C07K2317/76 , C07K2317/92
摘要： Agents (e.g., antibodies and fragments thereof) that bind specifically to IL 13 and modulate the ability of IL-13 to interact with IL-13 receptors and signaling mediators are disclosed.
摘要翻译： 公开了特异性结合IL13并调节IL-13与IL-13受体和信号传导介质相互作用的能力的试剂（例如抗体及其片段）。
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