发明申请
- 专利标题： COMPOSITIONS AND METHODS FOR WT1 SPECIFIC IMMUNOTHERAPY
- 专利标题（中）： WT1特异性免疫治疗的组合物和方法
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申请号： US12646703申请日： 2009-12-23
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公开(公告)号： US20100166738A1公开(公告)日： 2010-07-01
- 发明人: Alexander Gaiger , Martin A. Cheever
- 申请人： Alexander Gaiger , Martin A. Cheever
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; A61K39/00 ; A61K35/26 ; C12N5/00 ; A61K38/02 ; A61K31/7088 ; C07K2/00 ; C07K7/06 ; C07H21/00
摘要：
Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
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