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公开(公告)号：US20120301492A1
公开(公告)日：2012-11-29
申请号：US13481674
申请日：2012-05-25
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/0008 , A61K2039/55522 , A61K2039/55566 , A61K2039/55572 , C07K14/4748
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。
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2.发明授权Compositions and methods for the detection, diagnosis and therapy of hematological malignancies 失效用于检测，诊断和治疗血液恶性肿瘤的组合物和方法公开(公告)号：US08071732B2
公开(公告)日：2011-12-06
申请号：US11542681
申请日：2006-10-02
申请人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan D. Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
发明人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan D. Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
IPC分类号： C12P21/08
CPC分类号： C07K16/3061 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/6851 , A61K51/1018 , A61K2039/505 , C07K14/47 , C07K14/70535 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57426
摘要： Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
摘要翻译： 公开了用于血液恶性肿瘤，特别是B细胞白血病，淋巴瘤和多发性骨髓瘤的检测，诊断，预后和治疗的方法和组合物。 公开了用于在动物中引发对特定恶性肿瘤相关抗原性多肽及其抗原性多肽片段的免疫和T细胞应答的组合物，方法和试剂盒。 还公开了用于鉴定含有一种或多种血液恶性肿瘤相关组合物的细胞和生物样品的组合物和方法，以及用于检测和诊断这些疾病和受影响的细胞类型的方法。 还公开了诊断和治疗试剂盒，以及用于诊断，治疗和/或预防各种白血病和淋巴瘤的方法。
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公开(公告)号：US07901693B2
公开(公告)日：2011-03-08
申请号：US10002603
申请日：2001-10-30
申请人： Alexander Gaiger , Martin A Cheever
发明人： Alexander Gaiger , Martin A Cheever
IPC分类号： C07K14/435 , C07K14/47 , A61K39/00 , A61K38/17
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K48/00 , A61K2039/515 , C07K2319/00 , Y10S530/828
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
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4.发明授权公开(公告)号：US08920776B2
公开(公告)日：2014-12-30
申请号：US10501841
申请日：2003-01-22
申请人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan David Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
发明人： Alexander Gaiger , Paul A. Algate , Jane Mannion , Jonathan David Clapper , Aijun Wang , Nadia Ordonez , Lauren Carter , Patricia Dianne McNeill
IPC分类号： A61K51/10 , A61K39/395 , C07K16/30 , G01N33/574 , A61K39/00
CPC分类号： C07K16/3061 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/6851 , A61K51/1018 , A61K2039/505 , C07K14/47 , C07K14/70535 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57426
摘要： Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of variety of leukemias and lymphomas.
摘要翻译： 公开了用于血液恶性肿瘤，特别是B细胞白血病，淋巴瘤和多发性骨髓瘤的检测，诊断，预后和治疗的方法和组合物。 公开了用于在动物中引发对特定恶性肿瘤相关抗原性多肽及其抗原性多肽片段的免疫和T细胞应答的组合物，方法和试剂盒。 还公开了用于鉴定含有一种或多种血液恶性肿瘤相关组合物的细胞和生物样品的组合物和方法，以及用于检测和诊断这些疾病和受影响的细胞类型的方法。 还公开了诊断和治疗试剂盒，以及用于诊断，治疗和/或预防多种白血病和淋巴瘤的方法。
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公开(公告)号：US20100166738A1
公开(公告)日：2010-07-01
申请号：US12646703
申请日：2009-12-23
IPC分类号： A61K39/395 , A61K39/00 , A61K35/26 , C12N5/00 , A61K38/02 , A61K31/7088 , C07K2/00 , C07K7/06 , C07H21/00
CPC分类号： A61K39/0011 , A61K2039/55522 , A61K2039/55566 , A61K2039/55572 , Y10S514/885 , Y10S530/806 , Y10S530/828
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。
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公开(公告)号：US07553494B2
公开(公告)日：2009-06-30
申请号：US10427717
申请日：2003-04-30
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/515 , A61K2039/53 , A61K2039/55572 , A61K2039/55577 , C07K14/4748 , C07K2319/00 , C12N2799/021 , C12N2799/022 , C12N2799/023 , C12N2799/026 , Y10S530/806
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。
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公开(公告)号：US20090312403A1
公开(公告)日：2009-12-17
申请号：US12470408
申请日：2009-05-21
IPC分类号： A61K31/7088 , C07H21/00 , C12N15/63 , C12N1/21
CPC分类号： A61K39/0011 , A61K38/00 , A61K39/00 , A61K2039/515 , A61K2039/53 , A61K2039/55572 , A61K2039/55577 , C07K14/4748 , C07K2319/00 , C12N2799/021 , C12N2799/022 , C12N2799/023 , C12N2799/026 , Y10S530/806
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。
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公开(公告)号：US20080241268A1
公开(公告)日：2008-10-02
申请号：US11956201
申请日：2007-12-13
CPC分类号： A61K39/0011 , A61K2039/55522 , A61K2039/55566 , A61K2039/55572 , Y10S514/885 , Y10S530/806 , Y10S530/828
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
摘要翻译： 公开了治疗恶性疾病如白血病和癌症的组合物和方法。 所述组合物包含一种或多种WT1多核苷酸，WT1多肽，呈递WT1多肽的抗原呈递细胞，特异性结合WT1多肽的抗体; 或与WT1多肽特异性反应的T细胞。 这样的组合物可以用于例如预防和治疗转移性疾病。
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9.发明申请Compositions and methods for the detection, diagnosis and therapy of hematological malignancies 失效用于检测，诊断和治疗血液恶性肿瘤的组合物和方法公开(公告)号：US20070238182A1
公开(公告)日：2007-10-11
申请号：US11542681
申请日：2006-10-02
申请人： Alexander Gaiger , Paul Algate , Jane Mannion , Jonathan Clapper , Arjun Wang , Nadia Ordonez , Lauren Carter , Patricia McNeill
发明人： Alexander Gaiger , Paul Algate , Jane Mannion , Jonathan Clapper , Arjun Wang , Nadia Ordonez , Lauren Carter , Patricia McNeill
CPC分类号： C07K16/3061 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/6851 , A61K51/1018 , A61K2039/505 , C07K14/47 , C07K14/70535 , C07K16/18 , C07K16/28 , C07K2317/24 , C07K2317/55 , C07K2317/56 , C07K2317/569 , C07K2317/92 , C12Q1/6886 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158 , G01N33/57426
摘要： Disclosed are methods and compositions for the detection, diagnosis, prognosis, and therapy of hematological malignancies, and in particular, B cell leukemias, lymphomas and multiple myelomas. Disclosed are compositions, methods and kits for eliciting immune and T cell responses to specific malignancy-related antigenic polypeptides and antigenic polypeptide fragments thereof in an animal. Also disclosed are compositions and methods for use in the identification of cells and biological samples containing one or more hematological malignancy-related compositions, and methods for the detection and diagnosis of such diseases and affected cell types. Also disclosed are diagnostic and therapeutic kits, as well as methods for the diagnosis, therapy and/or prevention of a variety of leukemias and lymphomas.
摘要翻译： 公开了用于血液恶性肿瘤，特别是B细胞白血病，淋巴瘤和多发性骨髓瘤的检测，诊断，预后和治疗的方法和组合物。 公开了用于在动物中引发针对特定恶性肿瘤相关抗原性多肽及其抗原性多肽片段的免疫和T细胞应答的组合物，方法和试剂盒。 还公开了用于鉴定含有一种或多种血液恶性肿瘤相关组合物的细胞和生物样品的组合物和方法，以及用于检测和诊断这些疾病和受影响的细胞类型的方法。 还公开了诊断和治疗试剂盒，以及用于诊断，治疗和/或预防各种白血病和淋巴瘤的方法。
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公开(公告)号：US07144581B2
公开(公告)日：2006-12-05
申请号：US09785019
申请日：2001-02-15
IPC分类号： A61K38/16 , A61K39/00 , C07K14/435
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , A61K2039/515 , C07K2319/00 , Y10S514/885 , Y10S530/806
摘要： Compositions and methods for the therapy of malignant diseases, such as leukemia and cancer, are disclosed. The compositions comprise one or more of a WT1 polynucleotide, a WT1 polypeptide, an antigen-presenting cell presenting a WT1 polypeptide, an antibody that specifically binds to a WT1 polypeptide; or a T cell that specifically reacts with a WT1 polypeptide. Such compositions may be used, for example, for the prevention and treatment of metastatic diseases.
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