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发明申请
US20100197926A1 METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING 失效
生产含哌啶环的吲哚衍生物的方法

METHOD FOR PRODUCING INDOLE DERIVATIVE HAVING PIPERIDINE RING
摘要：
It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.
摘要（中）：

可商业上有利地制备1- {1- [2-（7-甲氧基-2,2-二甲基-4-氧代色满-8-y）乙基]哌啶-4-基} -N-甲基-1H-吲哚 -6-甲酰胺通过偶联（7-甲氧基-2,2-二甲基-4-氧代色满-8-基）乙醛，其通过将8-（2-羟乙基）-7-甲氧基-2,2-二甲基苯并二氢吡喃-2-酮 吡啶-4-酮与N-甲基-1-（哌啶-4-基）-1H-吲哚-6-甲酰胺反应。

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