摘要:
It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.
摘要:
It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.
摘要:
A crystal of 1-[1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)-ethyl]piperidin-4-yl]-N-methyl-1H-indole-6-carboxamide fumarate which has peaks at chemical shifts of about 124.0 ppm and about 26.8 ppm in a 13C solid NMR spectrum.
摘要:
A compound represented by the formula [I]: or a pharmacologically acceptable salt or ester thereof, wherein Ring A represents a five-membered aromatic heterocyclic group or the like fused with a non-aromatic ring group, which may be substituted, Ring B represents a phenyl group or the like which may be substituted, X1 represents a single bond or the like, R1 and R2 each represent a C1-6 alkyl group or the like, m represents an integer of 0 to 3, and n represents an integer of 0 to 2, is effective as a therapeutic agent for a disease caused by Aβ.
摘要:
In a mobile terminal provided with an encoded data recording function, there is assumed a condition in which a picture frame transmitted from the terminal of a communication partner is reproduced by means of decoding processing and is displayed on a LCD (34) during wireless TV phone communication. In this condition, when a user carries out a picture recording start operation, display picture data reproduced by means of decoding processing in the multimedia processing section (24) to be displayed on the LCD (34) are recorded in a main recording section (26).
摘要:
A main body controller provided in an image forming apparatus receives a VDP job from an external computer, and arranges image data of a reusable object and a variable object, which correspond to the VDP job, on a page for printout. An inspection controller performs inspection processing for printed matter for each page, and the main body controller preferentially stores image data of the reusable object, which corresponds to the page for which the printing has been determined to be defective as a result of inspection processing, in a cache unit. The main body controller acquires the reusable object, which corresponds to the page for which the printing has been determined to be defective, from the cache unit, and executes page reprint processing using the acquired reusable object.
摘要:
A manufacturing method of a plugged honeycomb structure including attaching a transparent sheet to an end face of a honeycomb structure; picking up an image of the end face; with respect to cells positioned at other than outermost peripheral portion of a honeycomb structure (usual cells), subjecting the picked-up image to image processing, recognizing positions to be plugged on said sheet, and with respect to cells positioned at outermost peripheral portion (outermost peripheral cells), positions of the cells are recognized based on an average cell pitch calculated from the positions of the cells, subjecting to a perforation treatment based on the recognized positions of the sheet, submerging an end portion into a plugging slurry in which a material of the plugging portions is slurried, filling holes made at the respective sheet with the slurry to form the plugging portions.
摘要:
There is provided a honeycomb structure including: porous partition walls separating and forming a plurality of cells extending between two end faces, and an outer peripheral wall formed unitarily with the partition walls. The cells include outermost peripheral portion partial cells each locating in an outermost peripheral portion of the honeycomb structure and having an incomplete cell cross section, a part of which is brought into contact with the outer peripheral wall, and complete cells each having a complete cell cross section other than the outermost peripheral portion partial cells. The complete cells and the outermost peripheral portion partial cells having plugging portions formed on one end portion so that an entire end face of the honeycomb structure shows a checkerwise plugging pattern, and the depth of the plugging portions in the outermost peripheral partial cells is smaller than that of the plugging portions in the complete cells.
摘要:
A compound represented by the formula (I): or a pharmacologically acceptable salt thereof, wherein Ar1 represents an imidazolyl group or the like which may be substituted with a C1-6 alkyl group, Ar2 represents a phenyl group or the like which may be substituted with a C1-6 alkoxy group, X1 represents a double bond or the like and Het represents a triazolyl group or the like which may be substituted with a C1-6 alkyl group or the like, is effective as a therapeutic or prophylactic agent for a disease caused by Aβ.
摘要:
There is provided a modulation circuit including a sampling unit that over-samples an input digital signal based on a multiplying clock signal, and outputs a first over-sampling signal, a first frequency conversion unit that outputs a first high-frequency signal based on the first over-sampling signal and a reference signal, a first filter unit that outputs a second high-frequency signal based on a second over-sampling signal obtained by delaying the first over-sampling signal by one clock and the reference signal, a second filter unit that outputs a third high-frequency signal based on a third over-sampling signal obtained by delaying the second over-sampling signal by one clock and the reference signal, and an adder unit that adds the first high-frequency signal, the second high-frequency signal, and the third high-frequency signal, and outputs an output signal.