公开(公告)号：US08110688B2

公开(公告)日：2012-02-07

申请号：US11914115

申请日：2006-11-05

申请人： Naoyuki Shimomura ,  Atsushi Kamada ,  Mamoru Miyazawa ,  Koichi Ito

发明人： Naoyuki Shimomura ,  Atsushi Kamada ,  Mamoru Miyazawa ,  Koichi Ito

IPC分类号： C07D405/14 ,  C07D311/22

CPC分类号： C07D405/14 ,  C07D311/22

摘要： It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.

摘要翻译： 可商业上有利地制备1- {1- [2-（7-甲氧基-2,2-二甲基-4-氧代色满-8-y）乙基]哌啶-4-基} -N-甲基-1H-吲哚 -6-甲酰胺通过偶联（7-甲氧基-2,2-二甲基-4-氧代色满-8-基）乙醛，其通过将8-（2-羟乙基）-7-甲氧基-2,2-二甲基苯并二氢吡喃-2-酮 吡啶-4-酮与N-甲基-1-（哌啶-4-基）-1H-吲哚-6-甲酰胺反应。

公开(公告)号：US20100197926A1

公开(公告)日：2010-08-05

申请号：US11914115

申请日：2006-11-05

申请人： Naoyuki Shimomura ,  Atsushi Kamada ,  Mamoru Miyazawa ,  Koichi Ito

发明人： Naoyuki Shimomura ,  Atsushi Kamada ,  Mamoru Miyazawa ,  Koichi Ito

IPC分类号： C07D405/14

CPC分类号： C07D405/14 ,  C07D311/22

摘要： It is possible to commercially advantageously prepare 1-{1-[2-(7-methoxy-2,2-dimethyl-4-oxochroman-8-y)ethyl]piperidin-4-yl}-N-methyl-1H-indole-6-carboxamide by coupling (7-methoxy-2,2-dimethyl-4-oxochroman-8-yl)acetaldehyde, which is obtained by oxidizing 8-(2-hydroxyethyl)-7-methoxy-2,2-dimethylchroman-4-one, with N-methyl-1-(piperidin-4-yl)-1H-indole-6-carboxamide.

摘要翻译： 可商业上有利地制备1- {1- [2-（7-甲氧基-2,2-二甲基-4-氧代色满-8-y）乙基]哌啶-4-基} -N-甲基-1H-吲哚 -6-甲酰胺通过偶联（7-甲氧基-2,2-二甲基-4-氧代色满-8-基）乙醛，其通过将8-（2-羟乙基）-7-甲氧基-2,2-二甲基苯并二氢吡喃-2-酮 吡啶-4-酮与N-甲基-1-（哌啶-4-基）-1H-吲哚-6-甲酰胺反应。

公开(公告)号：US20090192316A1

公开(公告)日：2009-07-30

申请号：US12097244

申请日：2006-12-20

申请人： Manabu Sasho ,  Keizo Sato ,  Jun Niijima ,  Mamoru Miyazawa ,  Shigeto Negi ,  Atsushi Kamada

发明人： Manabu Sasho ,  Keizo Sato ,  Jun Niijima ,  Mamoru Miyazawa ,  Shigeto Negi ,  Atsushi Kamada

IPC分类号： C07F9/6539

CPC分类号： C07F9/65583

摘要： An object of the present invention is to provide a process, or the like, suitable for the industrialization of effective deprotection reaction without using a toxic solvent as well as to provide a process, or the like, for preparing a water-soluble azole prodrug effectively. The present invention provides a process for preparing a salt represented by Formula (I); (wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) comprising the steps of: (a) carrying out a deprotection reaction of a compound represented by Formula (II); (wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) in the presence of a carbocation scavenger.

摘要翻译： 本发明的目的是提供一种适于工业化有效的脱保护反应而不使用有毒溶剂的方法，以及提供一种制备水溶性唑类药物的方法等。 。 本发明提供由式（I）表示的盐的制备方法。 （其中X表示在苯基的第4位或第5位键合的氟原子），包括以下步骤：（a）进行式（II）表示的化合物的脱保护反应; （其中X表示在苯基的4位或5位键合的氟原子）在碳阳离子清除剂存在下进行。

公开(公告)号：US07803949B2

公开(公告)日：2010-09-28

申请号：US12097244

申请日：2006-12-20

申请人： Manabu Sasho ,  Keizo Sato ,  Jun Niijima ,  Mamoru Miyazawa ,  Shigeto Negi ,  Atsushi Kamada

发明人： Manabu Sasho ,  Keizo Sato ,  Jun Niijima ,  Mamoru Miyazawa ,  Shigeto Negi ,  Atsushi Kamada

IPC分类号： C07F9/06

CPC分类号： C07F9/65583

摘要： An object of the present invention is to provide a process, or the like, suitable for the industrialization of effective deprotection reaction without using a toxic solvent as well as to provide a process, or the like, for preparing a water-soluble azole prodrug effectively. The present invention provides a process for preparing a salt represented by Formula (I); (wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) comprising the steps of: (a) carrying out a deprotection reaction of a compound represented by Formula (II); (wherein X represents a fluorine atom bonded at position 4 or position 5 of a phenyl group) in the presence of a carbocation scavenger.

摘要翻译： 本发明的目的是提供一种适于工业化有效的脱保护反应而不使用有毒溶剂的方法，以及提供一种制备水溶性唑类药物的方法等。 。 本发明提供由式（I）表示的盐的制备方法。 （其中X表示在苯基的第4位或第5位键合的氟原子），包括以下步骤：（a）进行式（II）表示的化合物的脱保护反应; （其中X表示在苯基的4位或5位键合的氟原子）在碳阳离子清除剂存在下进行。

公开(公告)号：US08399520B2

公开(公告)日：2013-03-19

申请号：US13048391

申请日：2011-03-15

申请人： Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

发明人： Shinichi Hamaoka ,  Noritaka Kitazawa ,  Kazumasa Nara ,  Atsushi Sasaki ,  Atsushi Kamada ,  Tadashi Okabe

IPC分类号： A61K31/137 ,  C07C217/84

CPC分类号： C07C217/22 ,  C07C215/78 ,  C07C217/18 ,  C07C217/78 ,  C07C217/84 ,  C07C219/34 ,  C07C323/25 ,  C07C2602/10 ,  C07D205/04 ,  C07D207/09 ,  C07D209/08 ,  C07D209/14 ,  C07D209/30 ,  C07D209/44 ,  C07D211/14 ,  C07D211/26 ,  C07D211/46 ,  C07D211/58 ,  C07D213/38 ,  C07D213/64 ,  C07D213/73 ,  C07D223/16 ,  C07D243/08 ,  C07D277/66 ,  C07D295/088 ,  C07D295/13 ,  C07D295/135 ,  C07D307/14 ,  C07D309/04 ,  C07D309/14 ,  C07D311/58 ,  C07D317/66 ,  C07D333/20 ,  C07D333/58 ,  C07D405/12 ,  C07D451/06 ,  C07D453/02 ,  C07D487/08 ,  C07D491/10 ,  C07F5/025 ,  C07F7/1804 ,  C07F7/2208

摘要： The present invention provides a compound represented by the following formula (I); [wherein T represents a single bond, a C1-C4 alkylene group which may have a substituent and the like; formula (I-1) represents a single bond or a double bond; A represents a single bond, a bivalent 5- to 14-membered heterocyclic group which may have a substituent and the like; Y represents a single bond and the like; Z represents a methylene group and the like; ring G represents a phenylene group and the like which may condense with a 5- to 6-membered ring and may have a heteroatom; Ra and Rb are the same as or different from each other and represent a hydrogen atom and the like; W represents a single bond and the like; R′ represents 1 to 4 independent hydrogen atoms and the like; and R″ represents 1 to 4 independent hydrogen atoms and the like] or a salt thereof, or a hydrate thereof.

摘要翻译： 本发明提供由下式（I）表示的化合物。 [其中T表示单键，可以具有取代基的C1-C4亚烷基等; 式（I-1）表示单键或双键; A表示单键，可以具有取代基的二价5〜14元杂环基等; Y表示单键等; Z表示亚甲基等; 环G表示可以用5-至6-元环缩合并可具有杂原子的亚苯基等; R a和R b彼此相同或不同，表示氢原子等; W表示单键等; R'表示1〜4个独立的氢原子等; R“表示1〜4个独立的氢原子等]或其盐或其水合物。

公开(公告)号：US08265841B2

公开(公告)日：2012-09-11

申请号：US12670089

申请日：2008-06-12

申请人： Atsushi Kamada

发明人： Atsushi Kamada

IPC分类号： G06F7/00 ,  G06F17/00 ,  G06F19/00

CPC分类号： F16H61/12 ,  F16H59/105 ,  F16H2061/1208 ,  F16H2061/1228

摘要： In a shift control device operative to determine shift positions based on an absolute positional information related to a mechanical displacement of a shift mechanism, it is intended that the shift positions are accurately determined regardless of disturbance and deterioration with time. It is determined as to whether a varying width of a position voltage PV representing absolute positional information relative to a varying width of a pulse count number CP representing relative positional information is larger than an varying allowable range. When a state, under which difference between the both variations is larger than the varying allowable range, continues beyond a determining time T, a determination is made that persistent disturbance is existed in the position voltage PV, and a correlation between the position voltage PV and the shift positions “P”, “R”, “N” and “D” is learnt and corrected. This allows the correlation to be corrected even if a variation occurs in the position voltage PV due to for instance variations in a disturbance magnetic field or an environmental temperature, a change with time of an output characteristic of a hall element 78, so that the shift position can be determined based on the position voltage PV with increased precision at all times.

摘要翻译： 在基于与换档机构的机械位移有关的绝对位置信息来确定换档位置的变速控制装置中，意图是随着时间而扰动和劣化而准确地确定换档位置。 确定表示相对于表示相对位置信息的脉冲计数值CP的变化宽度的绝对位置信息的位置电压PV的变化宽度是否大于可变容许范围。 当两个变化之间的差异大于变化容许范围的状态持续超过确定时间T时，确定位置电压PV中存在持续性干扰，并且确定位置电压PV和 学习并校正移位位置“P”，“R”，“N”和“D”。 即使由于例如扰动磁场或环境温度的变化，霍尔元件78的输出特性随时间的变化而导致位置电压PV发生变化，也能够校正相关性，使得偏移 可以随时随地提高精度的位置电压PV来确定位置。

公开(公告)号：US20120016558A1

公开(公告)日：2012-01-19

申请号：US13256299

申请日：2010-03-03

申请人： Koki Ueno ,  Atsushi Kamada ,  Takahiko Tsutsumi

发明人： Koki Ueno ,  Atsushi Kamada ,  Takahiko Tsutsumi

IPC分类号： B60R25/06

CPC分类号： B60R25/08

摘要： An antitheft device for vehicle includes store means storing a parking-lock canceling state activating a parking lock canceling operation and a parking lock state disabling the parking lock canceling operation alternatively, and switching means switching the parking lock state to the parking-lock canceling state upon success of a verification, an initial value of the store means being set to the parking-lock canceling state.

摘要翻译： 用于车辆的防盗装置包括：存储装置，存储启动停车锁取消操作的停车锁取消状态和停止停车锁取消操作的停车锁定状态，切换装置将停车锁定状态切换到停车锁定取消状态 验证的成功，存储装置的初始值被设置为驻车锁定取消状态。

公开(公告)号：US07811190B2

公开(公告)日：2010-10-12

申请号：US11909088

申请日：2006-06-26

申请人： Atsushi Tabata ,  Terufumi Miyazaki ,  Atsushi Kamada ,  Yutaka Taga

发明人： Atsushi Tabata ,  Terufumi Miyazaki ,  Atsushi Kamada ,  Yutaka Taga

IPC分类号： F16H3/72

CPC分类号： B60K6/445 ,  B60K1/02 ,  B60K5/04 ,  B60K6/26 ,  B60K6/365 ,  B60K6/387 ,  B60K6/40 ,  B60K6/405 ,  B60K6/547 ,  B60L11/123 ,  B60L11/14 ,  B60L2220/50 ,  B60W10/02 ,  F16H3/728 ,  F16H57/023 ,  F16H2037/0873 ,  F16H2057/02013 ,  Y02T10/6217 ,  Y02T10/6239 ,  Y02T10/641 ,  Y02T10/7077

摘要： A vehicular drive system including a first electric motor, a power distributing mechanism, and a second electric motor disposed on a first axis, and an automatic transmission portion disposed on a second axis parallel to the first axis, and a power transmitting member at an end of the first axis remote from an input rotary member and a rotary member at an end of the second axis remote from the input rotary member are connected to each other through a drive linkage, thereby a total axial dimension of the first electric motor, power distributing mechanism, and second electric motor and an axial dimension of the automatic transmission portion are substantially equal to each other, whereby the axial dimension of the drive system is reduced. A housing of the vehicular drive system includes mutually separate first, second, third, and fourth casing portions, so the drive system can be easily assembled.

摘要翻译： 一种车辆用驱动系统，包括第一电动机，动力分配机构和设置在第一轴线上的第二电动机，以及设置在平行于所述第一轴线的第二轴线上的自动变速器部分，以及端部的动力传递部件 远离输入旋转构件的远离输入旋转构件的第一轴和第二轴的端部的旋转构件通过驱动联动装置彼此连接，从而第一电动机的总轴向尺寸，动力分配 机构和第二电动机以及自动变速器部分的轴向尺寸基本上彼此相等，从而减小了驱动系统的轴向尺寸。 车辆驱动系统的壳体包括相互分离的第一，第二，第三和第四壳体部分，因此驱动系统可以容易地组装。

公开(公告)号：US20090326767A1

公开(公告)日：2009-12-31

申请号：US12310282

申请日：2007-08-31

申请人： Atsushi Kamada ,  Yasushi Hanaki ,  Naoki Taki ,  Akira Nagasaka ,  Yoshinobu Nozaki ,  Akira Nagae

发明人： Atsushi Kamada ,  Yasushi Hanaki ,  Naoki Taki ,  Akira Nagasaka ,  Yoshinobu Nozaki ,  Akira Nagae

IPC分类号： G06F17/00 ,  B60T8/24

CPC分类号： B60T1/005 ,  B60T2270/414 ,  F16H61/12 ,  F16H61/30 ,  F16H63/483 ,  F16H2061/122 ,  F16H2061/1292 ,  Y10T477/6414 ,  Y10T477/644

摘要： A vehicle control apparatus for a vehicle that includes a brake mechanism that produces braking force through the actuation of a first actuator and a shift mechanism that changes the shift position of a transmission through the actuation of a second actuator. The vehicle control apparatus includes: a controller that controls the electric power supplied to the first actuator and that controls the electric power supplied to the second actuator; a first electric power supply unit that supplies electric power to the controller; a second electric power supply unit that supplies electric power to the first actuator; and a third electric power supply unit that supplies electric power to the second actuator. An actuator control unit in the controller controls the electric power supplied to the second actuator from the second electric power supply unit or from the third electric power supply unit when the second actuator is not able to operate using the electric power supplied from the first electric power supply unit.

摘要翻译： 一种用于车辆的车辆控制装置，其包括通过致动第一致动器产生制动力的制动机构和通过致动第二致动器来改变变速器的换档位置的换档机构。 车辆控制装置包括：控制器，其控制供给到第一致动器的电力，并控制供给到第二致动器的电力; 向所述控制器供给电力的第一电力供给单元; 向第一致动器供给电力的第二电力供给单元; 以及向第二致动器供给电力的第三电力供给单元。 控制器中的致动器控制单元在第二致动器不能使用从第一电力供给的电力进行动作时，从第二电力供给部或第三电力供给部控制供给第二致动器的电力 供应单位。

公开(公告)号：US20090318261A1

公开(公告)日：2009-12-24

申请号：US11915888

申请日：2006-05-30

申请人： Atsushi Tabata ,  Yutaka Taga ,  Yuji Inoue ,  Atsushi Kamada

发明人： Atsushi Tabata ,  Yutaka Taga ,  Yuji Inoue ,  Atsushi Kamada

IPC分类号： B60W10/12 ,  B60K1/02 ,  B60W20/00

CPC分类号： B60W20/10 ,  B60K6/445 ,  B60K6/543 ,  B60L11/123 ,  B60L11/14 ,  B60L15/20 ,  B60L2240/12 ,  B60L2240/421 ,  B60L2240/423 ,  B60L2240/441 ,  B60L2240/443 ,  B60L2240/486 ,  B60L2240/507 ,  B60L2250/12 ,  B60L2250/24 ,  B60L2250/26 ,  B60L2270/145 ,  B60W10/08 ,  B60W10/115 ,  B60W20/00 ,  F16H3/728 ,  F16H2037/0873 ,  F16H2061/6603 ,  F16H2200/0047 ,  F16H2200/2012 ,  F16H2200/2048 ,  Y02T10/6217 ,  Y02T10/6239 ,  Y02T10/645 ,  Y02T10/7077 ,  Y02T10/72 ,  Y02T10/7275 ,  Y10T477/23 ,  Y10T477/606

摘要： In a vehicle driving apparatus including a differential mechanism capable of executing a differential action, a control device can make the driving apparatus small-size, improve fuel consumption, and increase output torque. A transmission mechanism can be switched to a continuously variable shifting state and a step variable shifting state, by a switching clutch or a switching brake. Also, with a switch control bringing the switching clutch into a half-engaged state, during an engine startup/running, while the differential portion is allowed to operate as the electrically controlled continuously variable transmission, a reaction force against an engine torque is generated by the half-engaged switching clutch. Thus, the engine torque not less than the torque bearable by a first electric motor can be inputted into the differential portion, thereby increasing the output torque.

摘要翻译： 在包括能够执行差速动作的差动机构的车辆用驱动装置中，控制装置能够使驱动装置小型化，提高燃料消耗，提高输出转矩。 通过切换离合器或切换制动器，能够将变速机构切换为无级变速状态和阶梯式变速状态。 此外，通过将开关离合器变为半接合状态的开关控制，在发动机启动/运转期间，当差动部分被允许作为电控无级变速器运行时，通过以下方式产生反对发动机转矩的反作用力： 半啮合切换离合器。 因此，可以将不小于由第一电动机承受的转矩的发动机扭矩输入到差速部分，从而增加输出转矩。