- 专利标题： Fc Variants with altered binding to FcRn
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申请号： US12697952申请日： 2010-02-01
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公开(公告)号： US20100234574A1公开(公告)日： 2010-09-16
- 发明人: Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- 申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
- 专利权人： XENCOR, INC.
- 当前专利权人： XENCOR, INC.
- 主分类号： C07K16/00
- IPC分类号： C07K16/00
摘要：
The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
公开/授权文献
- US08324351B2 Fc variants with altered binding to FcRn 公开/授权日：2012-12-04
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