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公开(公告)号：US20100234573A1
公开(公告)日：2010-09-16
申请号：US12697945
申请日：2010-02-01
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含相对于野生型人Fc区的至少一个修饰的变体Fc区，其中选自434S，252Y / 428L，252Y / 434S和428L / 434S的修饰，以及 编号是根据欧盟指数。
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公开(公告)号：US08367805B2
公开(公告)日：2013-02-05
申请号：US12341769
申请日：2008-12-22
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC分类号： C07K16/00 , C12P218/08 , A61K39/395 , A61K39/40 , A61K39/42 , C07K1/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含相对于野生型人Fc区的至少一个修饰的变体Fc区，其中选自434S，252Y / 428L，252Y / 434S和428L / 434S的修饰，以及 编号是根据欧盟指数。
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公开(公告)号：US08324351B2
公开(公告)日：2012-12-04
申请号：US12697952
申请日：2010-02-01
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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公开(公告)号：US08318907B2
公开(公告)日：2012-11-27
申请号：US12697945
申请日：2010-02-01
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含相对于野生型人Fc区的至少一个修饰的变体Fc区，其中选自434S，252Y / 428L，252Y / 434S和428L / 434S的修饰，以及 编号是根据欧盟指数。
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公开(公告)号：US20120088905A1
公开(公告)日：2012-04-12
申请号：US13326776
申请日：2011-12-15
申请人： AARON KEITH CHAMBERLAIN , BASSIL I. DAHIYAT , JOHN R. DESJARLAIS , SHER BAHADUR KARKI , GREGORY ALAN LAZAR
发明人： AARON KEITH CHAMBERLAIN , BASSIL I. DAHIYAT , JOHN R. DESJARLAIS , SHER BAHADUR KARKI , GREGORY ALAN LAZAR
IPC分类号： C07K16/28
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含增加血清半衰期的双突变428L / 434S的变体Fc区，编号是根据EU指数。
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公开(公告)号：US20110110928A1
公开(公告)日：2011-05-12
申请号：US13008165
申请日：2011-01-18
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC分类号： A61K39/395 , A61P37/00 , A61P29/00 , A61P31/00 , A61P25/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含增加血清半衰期的双突变428L / 434S的变体Fc区，编号是根据EU指数。
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公开(公告)号：US20090041770A1
公开(公告)日：2009-02-12
申请号：US11932151
申请日：2007-10-31
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/082 , C07K16/22 , C07K16/2878 , C07K16/2893 , C07K16/32 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90
摘要： The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.
摘要翻译： 本申请涉及优化的IgG免疫球蛋白变体，其产生的工程方法及其应用，特别是用于治疗目的。
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公开(公告)号：US08394925B2
公开(公告)日：2013-03-12
申请号：US13326776
申请日：2011-12-15
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising the double mutation 428L/434S that increases serum half-life and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含增加血清半衰期的双突变428L / 434S的变体Fc区，编号是根据EU指数。
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公开(公告)号：US08338574B2
公开(公告)日：2012-12-25
申请号：US12697903
申请日：2010-02-01
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
摘要翻译： 本申请涉及包含相对于野生型人Fc区的至少一个修饰的变体Fc区，其中选自434S，252Y / 428L，252Y / 434S和428L / 434S的修饰，以及 编号是根据欧盟指数。
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公开(公告)号：US20100234575A1
公开(公告)日：2010-09-16
申请号：US12697960
申请日：2010-02-01
申请人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
发明人： Aaron Keith Chamberlain , Bassil I. Dahiyat , John R. Desjarlais , Sher Bahadur Karki , Gregory Alan Lazar
IPC分类号： C07K16/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K14/7151 , C07K16/082 , C07K16/22 , C07K16/241 , C07K16/2863 , C07K16/2866 , C07K16/2893 , C07K16/2896 , C07K16/32 , C07K16/4291 , C07K2317/24 , C07K2317/52 , C07K2317/524 , C07K2317/526 , C07K2317/90 , C07K2319/30 , Y02A50/484
摘要： The present application relates to a variant Fc region comprising at least one modification relative to a wild-type human Fc region, where the modification selected from the group consisting of 434S, 252Y/428L, 252Y/434S, and 428L/434S, and the numbering is according to the EU index.
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