公开(公告)号：US12215165B2

公开(公告)日：2025-02-04

申请号：US17549706

申请日：2021-12-13

Applicant: Xencor, Inc.

Inventor： Aaron Keith Chamberlain ,  John R. Desjarlais ,  Sher Bahadur Karki ,  Gregory Alan Lazar ,  Jost Vielmetter ,  Sean C. Yoder

IPC: C07K16/00 ,  A61K39/395 ,  A61K39/40 ,  C07K16/28 ,  C07K16/32 ,  C12P21/08

Abstract: The present application relates to optimized IgG immunoglobulin variants, engineering methods for their generation, and their application, particularly for therapeutic purposes.

公开(公告)号：US20240392025A1

公开(公告)日：2024-11-28

申请号：US18694877

申请日：2022-09-27

Applicant: Xencor, Inc.

Inventor： Gregory Moore

IPC: C07K16/28

Abstract: Provided herein are novel BCMA binding domain compositions and anti-BCMA antibodies that include such BCMA binding domains.

公开(公告)号：US20240360220A1

公开(公告)日：2024-10-31

申请号：US18647843

申请日：2024-04-26

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  John R. Desjarlais ,  Bhavika R. Patel

IPC: C07K16/28

CPC classification number: C07K16/283 ,  C07K2317/51 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/53 ,  C07K2317/55

Abstract: Provided herein are multimeric proteins that reduce the promiscuous pairing of monomers of the multimeric protein and/or promote the proper pairing of monomers of the multimeric proteins, as well as methods of using such multimeric proteins.

公开(公告)号：US12129309B2

公开(公告)日：2024-10-29

申请号：US17736475

申请日：2022-05-04

Applicant: Xencor, Inc.

Inventor： Matthew Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal

IPC: C07K16/40 ,  C07K16/18 ,  C07K16/28 ,  C07K16/30 ,  A61K39/00

CPC classification number: C07K16/40 ,  C07K16/18 ,  C07K16/2809 ,  C07K16/2896 ,  C07K16/3061 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/92

Abstract: The present invention is directed to heterodimeric antibodies that bind CD3 and CD38.

公开(公告)号：US20240279317A1

公开(公告)日：2024-08-22

申请号：US18414799

申请日：2024-01-17

Applicant: Allergan, Inc. ,  Xencor, Inc.

Inventor： Peter C. Baciu ,  Yanbin LIANG ,  Jason Guu ,  Matthew Bernett ,  Umesh Muchhal ,  John Desjarlais

IPC: C07K16/18 ,  A61K39/00 ,  A61K39/395

CPC classification number: C07K16/18 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/3955 ,  C07K2317/24 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/76

Abstract: The present disclosure relates to antibodies and polynucleotides encoding the same, that may be used to prevent, control, or reduce the activity of the complement pathway. In addition, the disclosure is directed to compositions and methods for diagnosing and treating diseases mediated by or involving complement C5. Specifically, the disclosure is related to C5 antibodies.

公开(公告)号：US20240262907A1

公开(公告)日：2024-08-08

申请号：US18248030

申请日：2021-10-06

Applicant: Xencor, Inc.

Inventor： Ying DING ,  John R. DESJARLAIS ,  Bart BURINGTON ,  Raphael CLYNES ,  Debra J. ZACK ,  Paul FOSTER ,  Joel GUTHRIDGE

IPC: C07K16/28 ,  A61P37/06 ,  G01N33/564

CPC classification number: C07K16/2803 ,  A61P37/06 ,  G01N33/564 ,  C07K2317/31 ,  G01N2800/104 ,  G01N2800/52

Abstract: The disclosure relates to methods of detecting one or more biomarkers. and/or treating autoimmune diseases such as systemic lupus erythematous (SLE) with an anti-CD19 antibody based on the presence of such biomarkers. The biomarkers can be separate or in combination, and their detection can be used in multiple different methods.

公开(公告)号：US12054545B2

公开(公告)日：2024-08-06

申请号：US17542341

申请日：2021-12-03

Applicant: Xencor, Inc.

Inventor： Gregory Moore ,  Rumana Rashid ,  Sung-Hyung Lee ,  Paul Foster

IPC: A61P35/00 ,  C07K16/28 ,  A61K39/00

CPC classification number: C07K16/2809 ,  A61P35/00 ,  C07K16/2869 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/73

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2).

公开(公告)号：US20240166705A1

公开(公告)日：2024-05-23

申请号：US18503935

申请日：2023-11-07

Applicant: Xencor, Inc.

Inventor： Alex NISTHAL ,  John DESJARLAIS ,  Gregory MOORE ,  Sung-Hyung LEE ,  Matthew Adam DRAGOVICH

IPC: C07K14/54 ,  C07K16/28 ,  C07K16/30

CPC classification number: C07K14/54 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2809 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K2317/31 ,  C07K2317/622 ,  C07K2319/30

Abstract: Provided herein are variant human IL18 proteins including proteins and constructs including such. Various variant IL18 proteins with modifications to reduce heterogeneity and/or reduce affinity/potency and/or improve stability and/or improve production yield are also described. Also provided are IL18-Fc fusion proteins that include an empty-Fc domain and an IL18 protein connected to another Fc domain. Also provided herein are IL18Fc fusion proteins that bind CD3 and a tumor target antigen.

公开(公告)号：US20240150471A1

公开(公告)日：2024-05-09

申请号：US18502668

申请日：2023-11-06

Applicant: Xencor, Inc.

Inventor： Matthew S. Faber

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/32

CPC classification number: C07K16/2851 ,  C07K16/28 ,  C07K16/2803 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/283 ,  C07K16/2863 ,  C07K16/2866 ,  C07K16/2878 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3007 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/52 ,  C07K2317/732

Abstract: Described herein are antibodies, including multispecific antibodies, that bind to NK cells, optionally a tumor target antigen (TTA) and have increased binding to the CD16A receptor. The antibodies can include an NK cell antigen binding domain (ABD) that binds to the extracellular domain of an NK cell antigen such as NKG2D, NKp30, and NKp46.

公开(公告)号：US11945880B2

公开(公告)日：2024-04-02

申请号：US17542342

申请日：2021-12-03

Applicant: Xencor, Inc.

Inventor： Matthew J. Bernett ,  Gregory Moore ,  John Desjarlais ,  Seung Chu ,  Rumana Rashid ,  Umesh Muchhal ,  Sung-Hyung Lee

IPC: C07K16/30 ,  C07K16/28 ,  C07K16/40 ,  C07K16/46 ,  A61K39/00

CPC classification number: C07K16/468 ,  C07K16/2809 ,  C07K16/2866 ,  C07K16/2887 ,  C07K16/2896 ,  C07K16/30 ,  C07K16/3061 ,  C07K16/40 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/515 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/526 ,  C07K2317/528 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/60 ,  C07K2317/622 ,  C07K2317/64 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present invention is directed to novel heterodimeric antibodies.