发明申请
US20110014164A1 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
审中-公开
使用小分子化合物有效诱导大脑干细胞
- 专利标题: EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS
- 专利标题(中): 使用小分子化合物有效诱导大脑干细胞
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申请号: US12867615申请日: 2009-02-13
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公开(公告)号: US20110014164A1公开(公告)日: 2011-01-20
- 发明人: Danwei Huangfu , Douglas A. Melton , Rene Maehr
- 申请人: Danwei Huangfu , Douglas A. Melton , Rene Maehr
- 申请人地址: US MA Cambridge
- 专利权人: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人: PRESIDENT AND FELLOWS OF HARVARD COLLEGE
- 当前专利权人地址: US MA Cambridge
- 国际申请: PCT/US09/34102 WO 20090213
- 主分类号: A61K35/12
- IPC分类号: A61K35/12 ; C12N5/07 ; C12N5/0797 ; C12N5/071 ; G01N33/566 ; A61P25/28 ; A61P17/02 ; A61P9/00 ; A61P9/10 ; A61P1/16 ; A61P3/10 ; A61P5/14 ; A61P11/00 ; A61P19/08 ; A61P35/02 ; A61P37/02 ; A61P7/06
摘要:
The disclosure features a method of producing an induced pluripotent stem cell a somatic cell. The method includes contacting a somatic cell with a DNA methyl transferase inhibitor or a histone deacetylase (HDAC) inhibitor, or a combination thereof, to produce a pluripotent stem cell.
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