发明申请
US20110020388A1 TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
审中-公开
具有敏感性释放免疫调节剂的靶向合成纳米颗粒
- 专利标题： TARGETED SYNTHETIC NANOCARRIERS WITH PH SENSITIVE RELEASE OF IMMUNOMODULATORY AGENTS
- 专利标题（中）： 具有敏感性释放免疫调节剂的靶向合成纳米颗粒
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申请号： US12788260申请日： 2010-05-26
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公开(公告)号： US20110020388A1公开(公告)日： 2011-01-27
- 发明人: CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
- 申请人： CHARLES ZEPP , Yun Gao , Mark J. Keegan , Sam Baldwin , Fen-ni Fu , Lloyd Johnston , Grayson B. Lipford
- 申请人地址： US MA Watertown
- 专利权人： Selecta Biosciences, Inc.
- 当前专利权人： Selecta Biosciences, Inc.
- 当前专利权人地址： US MA Watertown
- 主分类号： A61K39/385
- IPC分类号： A61K39/385 ; C07D471/04 ; C07D473/34 ; C07H21/00 ; A61P37/02
摘要：
This invention relates to compositions, and related methods, of synthetic nanocarriers that target sites of action in cells, such as antigen presenting cells (APCs), and comprise immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner. Also disclosed are compositions and methods relating to synthetic nanocarriers that encapsulate labile immunomodulatory agents that dissociate from the synthetic nanocarriers in a pH sensitive manner.
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