-
公开(公告)号：US09994443B2
公开(公告)日：2018-06-12
申请号：US13289211
申请日：2011-11-04
申请人： Charles Zepp , Yun Gao
发明人： Charles Zepp , Yun Gao
IPC分类号： B82Y5/00 , C07D401/04 , C08G73/02 , C08G65/26 , C08G65/329 , C08G65/333 , A61K39/00 , A61K39/385 , A61K47/60 , A61K47/59
CPC分类号： B82Y5/00 , A61K39/0013 , A61K39/385 , A61K47/59 , A61K47/60 , C07D401/04 , C08G65/2609 , C08G65/2618 , C08G65/329 , C08G65/33317 , C08G65/33396 , C08G73/0206 , C08G73/0233 , C08L2203/02
摘要： Provided herein are compounds and related composition and methods that may be used to raise an antibody response to nicotinic compounds, in some embodiments.
-
公开(公告)号：US20110293723A1
公开(公告)日：2011-12-01
申请号：US13116556
申请日：2011-05-26
IPC分类号： A61K9/14 , A61K39/385 , A61K39/12 , A61K39/10 , A61K39/145 , A61K39/29 , A61K39/25 , A61K39/165 , A61K39/20 , A61K39/09 , A61K39/13 , A61K39/205 , A61K39/15 , A61K39/285 , A61K39/235 , A61K39/125 , A61K39/155 , A61K39/106 , A61K39/118 , A61K39/08 , A61K39/05 , A61K39/108 , A61K39/04 , A61K39/095 , A61K39/104 , A61K39/112 , A61K39/085 , A61P35/00 , A61P31/00 , A61P31/04 , A61P31/10 , A61P31/12 , A61P31/14 , A61P31/16 , A61P31/20 , A61P31/22 , A61K38/21 , A61K39/00 , B82Y5/00
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are dosage forms and related methods, that include a first population of synthetic nanocarriers that have one or more first antigens coupled to them, one or more second antigens that are not coupled to the synthetic nanocarriers, and a pharmaceutically acceptable excipient.
摘要翻译： 公开了剂型和相关方法，其包括具有一个或多个与其偶联的第一抗原的第一批合成纳米载体，一种或多种不与合成纳米载体偶联的第二抗原和药学上可接受的赋形剂。
-
公开(公告)号：US20070232622A1
公开(公告)日：2007-10-04
申请号：US11543314
申请日：2006-10-04
IPC分类号： A61K31/519 , A61P37/00 , C07D239/70 , C12N5/00
CPC分类号： A61K31/437 , A61K31/122 , A61K31/382 , A61K31/4462 , A61K31/4709 , A61K31/496 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/553 , C07D221/10 , C07D239/94 , C07D239/95 , C07D405/12
摘要： The invention provides methods and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a small molecule having a core structure including at least two rings. Certain of the compounds are 4-primary amino quinolines. Many of the compounds and methods are useful specifically for inhibiting immune stimulation involving at least one of TLR9, TLR8, TLR7, and TLR3. The methods may have use in the treatment of autoimmunity, inflammation, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.
摘要翻译： 本发明提供了用于通过Toll样受体调节信号传导的方法和组合物。 所述方法包括使TLR表达细胞与具有包含至少两个环的核心结构的小分子接触。 某些化合物是4-伯氨基喹啉。 许多化合物和方法专门用于抑制涉及TLR9，TLR8，TLR7和TLR3中的至少一种的免疫刺激。 该方法可用于治疗自身免疫，炎症，过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。
-
4.发明申请SYNTHETIC NANOCARRIERS WITH REACTIVE GROUPS THAT RELEASE BIOLOGICALLY ACTIVE AGENTS 审中-公开具有生物活性剂的反应性组合物的合成纳米颗粒公开(公告)号：US20120171229A1
公开(公告)日：2012-07-05
申请号：US13341020
申请日：2011-12-30
申请人： Charles Zepp , Yun Gao
发明人： Charles Zepp , Yun Gao
IPC分类号： A61K47/48 , C07H23/00 , A61K39/00 , A61P37/02 , A61P31/12 , C08G63/08 , B32B15/02 , C07K17/02 , A61P35/00 , B82Y5/00 , B82Y30/00
CPC分类号： C08G63/912 , A61K39/39 , A61K47/593 , A61K47/6923 , A61K47/6929 , B82Y5/00 , B82Y40/00 , C07H15/252 , C08G63/08 , C12N2770/32023 , Y10T428/2989
摘要： This invention relates to compositions, and related compounds and methods, of conjugates of synthetic nanocarriers, or components thereof, and biologically active agents, such as immunomodulatory agents, antigens, anticancer agents or antiviral agents. The biologically active agents are released from the synthetic nanocarriers in the presence of a reducing agent or by reaction with a thiol.
摘要翻译： 本发明涉及合成纳米载体或其组分的缀合物和生物活性剂如免疫调节剂，抗原，抗癌剂或抗病毒剂的组合物及相关化合物和方法。 生物活性剂在还原剂存在下或通过与硫醇反应从合成纳米载体中释放出来。
-
公开(公告)号：US20120114677A1
公开(公告)日：2012-05-10
申请号：US13289211
申请日：2011-11-04
申请人： Charles Zepp , Yun Gao
发明人： Charles Zepp , Yun Gao
CPC分类号： B82Y5/00 , A61K39/0013 , A61K39/385 , A61K47/59 , A61K47/60 , C07D401/04 , C08G65/2609 , C08G65/2618 , C08G65/329 , C08G65/33317 , C08G65/33396 , C08G73/0206 , C08G73/0233 , C08L2203/02
摘要： Provided herein are compounds and related composition and methods that may be used to raise an antibody response to nicotinic compounds, in some embodiments.
摘要翻译： 在一些实施方案中，本文提供可用于提高对烟碱化合物的抗体应答的化合物和相关组合物和方法。
-
公开(公告)号：US20120027806A1
公开(公告)日：2012-02-02
申请号：US13116542
申请日：2011-05-26
申请人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
发明人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K9/14 , A61K39/39 , A61P35/00 , A61P31/00 , A61P25/28 , A61P25/30 , A61P17/00 , A61P11/06 , A61P11/00 , A61K39/00 , A61P3/00 , B82Y5/00
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/403 , Y02A50/466 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
摘要翻译： 公开了具有偶联佐剂组合物的合成纳米载体组合物以及相关方法。
-
公开(公告)号：US20090045617A1
公开(公告)日：2009-02-19
申请号：US12214492
申请日：2008-06-19
申请人： Nabil M. Lawandy , Tim Driscoll , Jeff Conroy , William Goltsos , Charles Zepp
发明人： Nabil M. Lawandy , Tim Driscoll , Jeff Conroy , William Goltsos , Charles Zepp
IPC分类号： B42D15/00
CPC分类号： C09D11/037 , B42D25/382 , C09D11/50 , G07D7/12 , G07D7/1205
摘要： Systems and methods of providing a covert security marking for items such as documents, packaging, credit cards, and other valuable goods to combat the steady increase in forgery, counterfeiting, and other fraudulent activities is presented. A spectrally narrow, near infrared ink system serves as the basis of a covert security feature for items of value. Alternatively, or in combination, metal oxides having a substantially narrow absorption band and a maximum absorption wavelength of electromagnetic radiation in the near infrared range are also utilized.
摘要翻译： 介绍了为文件，包装，信用卡和其他有价值物品等物品提供隐蔽安全标记的系统和方法，以防止伪造，伪造和其他欺诈活动的稳步增长。 光谱窄的近红外墨水系统作为价值物品的秘密安全特征的基础。 或者或组合地，还利用具有近红外范围的电磁辐射的基本上窄的吸收带和最大吸收波长的金属氧化物。
-
公开(公告)号：US20070060555A1
公开(公告)日：2007-03-15
申请号：US11599124
申请日：2006-11-14
申请人： Mark Currie , Steven Jones , Charles Zepp
发明人： Mark Currie , Steven Jones , Charles Zepp
IPC分类号： A61K31/573 , A61K31/56 , C07J5/00
CPC分类号： C07J5/00 , C07J5/0076 , C07J5/0092 , C07J71/0031 , Y10S514/826 , Y10S514/886
摘要： Compounds are disclosed of the formula in which R3 is C8 to C24 hydrocarbon or the residue of misoprostol. The compounds are useful for treating rhinitis and asthma, particularly by inhalation, and for treating inflammation, particularly by local or topical administration.
摘要翻译： 公开了下列化学式的化合物，其中R 3为C 8 -C 24烃或米索前列醇的残基。 该化合物可用于治疗鼻炎和哮喘，特别是通过吸入治疗和治疗炎症，特别是通过局部或局部给药治疗炎症。
-
公开(公告)号：US20180043023A1
公开(公告)日：2018-02-15
申请号：US15684896
申请日：2017-08-23
申请人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
发明人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K45/06 , A61K9/51 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K47/22 , A61K47/02 , A61K39/39 , A61K39/35 , A61K39/00 , A61K39/385 , A61K47/24
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/401 , Y02A50/403 , Y02A50/466 , Y02A50/469 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
-
公开(公告)号：US09066978B2
公开(公告)日：2015-06-30
申请号：US13116542
申请日：2011-05-26
申请人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
发明人： Petr Ilyinskii , Grayson B. Lipford , Charles Zepp
IPC分类号： A61K9/00 , A61K45/00 , A61K47/06 , A61K39/00 , A61K39/38 , A61K45/06 , A61K9/51 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/48
CPC分类号： A61K45/06 , A61K9/5153 , A61K31/4745 , A61K31/7115 , A61K33/06 , A61K39/0005 , A61K39/0013 , A61K39/35 , A61K39/385 , A61K39/39 , A61K47/02 , A61K47/22 , A61K47/24 , A61K47/58 , A61K47/593 , A61K47/60 , A61K47/646 , A61K47/68 , A61K47/6921 , A61K47/6929 , A61K47/6931 , A61K2039/54 , A61K2039/541 , A61K2039/542 , A61K2039/543 , A61K2039/555 , A61K2039/55511 , A61K2039/55522 , A61K2039/55555 , A61K2039/55561 , A61K2039/6093 , A61K2039/70 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/396 , Y02A50/403 , Y02A50/466 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Disclosed are synthetic nanocarrier compositions with coupled adjuvant compositions as well as related methods.
摘要翻译： 公开了具有偶联佐剂组合物的合成纳米载体组合物以及相关方法。
-
-
-
-
-
-
-
-
-
搜索结果
26 条记录 (耗时 0.027 秒)
