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    Highly efficient delivery of a large therapeutic mass aerosol
    1.
    发明授权
    Highly efficient delivery of a large therapeutic mass aerosol 有权
    高效率地传送大量治疗性气溶胶

    公开(公告)号：US08628754B2

    公开(公告)日：2014-01-14

    申请号：US13334236

    申请日：2011-12-22

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/14

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

    摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。

    HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC MASS AEROSOL
    4.
    发明申请
    HIGHLY EFFICIENT DELIVERY OF A LARGE THERAPEUTIC MASS AEROSOL 审中-公开
    高效治疗大剂量气溶胶的高效运输

    公开(公告)号：US20090068274A1

    公开(公告)日：2009-03-12

    申请号：US12253449

    申请日：2008-10-17

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/14 ,  A61P11/00

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.

    摘要翻译： 用于在单个呼吸激活步骤或单次呼吸中将药物递送至肺部系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有小于 0.4克/厘米3，并输送至少约50％的颗粒。 颗粒能够携带。 试剂是（1）部分喷雾干燥预混合物，由此加入到颗粒中，（2）加入到单独制备的颗粒中，使得试剂与颗粒化学缔合，或（3）混合 试剂与颗粒混合并与颗粒共同传送。 还公开了包含振实密度小于0.4g / cm 3的载体颗粒和包含试剂的组合物的可吸入组合物。 还包括递送这些可呼吸组合物的方法。

    Highly efficient delivery of a large therapeutic mass aerosol
    5.
    发明授权
    Highly efficient delivery of a large therapeutic mass aerosol 有权
    高效率地传送大量治疗性气溶胶

    公开(公告)号：US06921528B2

    公开(公告)日：2005-07-26

    申请号：US10681416

    申请日：2003-10-08

    申请人： David A. Edwards ,  Richard P. Batvcky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batvcky ,  Lloyd Johnston

    IPC分类号： A61K9/12 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61K31/137 ,  A61K31/198 ,  A61K31/46 ,  A61K31/56 ,  A61K38/27 ,  A61K38/28 ,  A61K39/395 ,  A61L9/04 ,  B05D7/14

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.

    摘要翻译： 在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒 超过0.4g / cm 3，并输送至少约50％的质量的颗粒。 在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。 容器可具有至少0.37厘米3的体积。

    High efficient delivery of a large therapeutic mass aerosol
    6.
    发明授权
    High efficient delivery of a large therapeutic mass aerosol 有权
    高效率输送大量治疗性气溶胶

    公开(公告)号：US06858199B1

    公开(公告)日：2005-02-22

    申请号：US09591307

    申请日：2000-06-09

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/12 ,  A61K9/00 ,  A61K9/14 ,  A61K9/16 ,  A61K9/72 ,  A61K31/137 ,  A61K31/198 ,  A61K31/46 ,  A61K31/56 ,  A61K38/27 ,  A61K38/28 ,  A61K39/395 ,  A61L9/04 ,  B05D7/14

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single, breath-activated step, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. Another method of delivering a therapeutic dose of a bioactive agent to the pulmonary system, in a single breath, includes administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of at least 0.4 g/cm3 and deliver at least about 10 milligrams of the bioactive agent. The receptacle can have a volume of at least 0.37 cm3.

    摘要翻译： 在单一呼吸激活步骤中将治疗剂量的生物活性剂递送到肺系统的方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有较小振幅密度的颗粒 超过0.4g / cm 3并且输送至少约50％的质量的颗粒。 在单次呼吸中将治疗剂量的生物活性剂递送到肺系统的另一种方法包括从包围大量颗粒的容器向受试者的呼吸道施用具有至少0.4g / 并输送至少约10毫克的生物活性剂。 容器可具有至少0.37厘米3的体积。

    Highly efficient delivery of a large therapeutic mass aerosol
    9.
    发明授权
    Highly efficient delivery of a large therapeutic mass aerosol 有权

    公开(公告)号：US07556798B2

    公开(公告)日：2009-07-07

    申请号：US09878146

    申请日：2001-06-08

    申请人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    发明人： David A. Edwards ,  Richard P. Batycky ,  Lloyd Johnston

    IPC分类号： A61K9/12 ,  A61K9/14

    CPC分类号： A61K9/14 ,  A61K9/0075 ,  A61K9/1617 ,  A61K31/198

    摘要： A method for delivering an agent to the pulmonary system, in a single, breath-activated step or a single breath, comprises administering from a receptacle enclosing a mass of particles, to a subject's respiratory tract, particles which have a tap density of less than 0.4 g/cm3 and deliver at least about 50% of the mass of particles. The particles are capable of carrying agents. The agent is (1) part of the spray-drying pre-mixture and thereby incorporated into the particles, (2) added to separately-prepared particles so that the agent is in chemical association with the particles or (3) blended so that the agent is mixed with, and co-delivered with the particles.Respirable compositions comprising carrier particles having a tap density of less than 0.4 g/cm3 and a composition comprising an agent are also disclosed. Methods of delivering these respirable compositions are also included.