发明申请
- 专利标题: DUAL-ACTING OXAZOLE ANTIHYPERTENSIVE AGENTS
- 专利标题(中): 双作用奥沙唑抗菌剂
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申请号: US12835999申请日: 2010-07-14
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公开(公告)号: US20110021527A1公开(公告)日: 2011-01-27
- 发明人: Paul R. FATHEREE , Ryan HUDSON , Robert Murray MCKINNELL
- 申请人: Paul R. FATHEREE , Ryan HUDSON , Robert Murray MCKINNELL
- 主分类号: A61K31/422
- IPC分类号: A61K31/422 ; C07D413/10 ; C07D263/34 ; A61K31/421 ; A61K31/4439 ; A61K31/5377 ; C07D413/14 ; A61K31/4245 ; C07D413/06 ; A61K31/497 ; A61K31/506 ; A61K31/5575 ; A61P9/12
摘要:
In one aspect, the invention relates to compounds having the formula: wherein: Ar, Z, R3, R4 and R5 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
公开/授权文献
- US08372984B2 Dual-acting oxazole antihypertensive agents 公开/授权日:2013-02-12
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