发明申请
US20110034461A1 SF5 DERIVATIVES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS
有权
作为PAR1抑制剂的SF5衍生物，其生产和用作药物
- 专利标题： SF5 DERIVATIVES AS PAR1 INHIBITORS, PRODUCTION THEREOF, AND USE AS MEDICAMENTS
- 专利标题（中）： 作为PAR1抑制剂的SF5衍生物，其生产和用作药物
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申请号： US12851229申请日： 2010-08-05
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公开(公告)号： US20110034461A1公开(公告)日： 2011-02-10
- 发明人: Uwe HEINELT , Volkmar WEHNER , Matthias HERRMANN , Karl SCHOENAFINGER , Henning STEINHAGEN
- 申请人： Uwe HEINELT , Volkmar WEHNER , Matthias HERRMANN , Karl SCHOENAFINGER , Henning STEINHAGEN
- 申请人地址： FR Paris
- 专利权人： sanofi-aventis
- 当前专利权人： sanofi-aventis
- 当前专利权人地址： FR Paris
- 优先权： EP08290115.8 20080205
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D209/44 ; A61K31/4035 ; C07D413/10 ; C07D403/10 ; C07C381/00 ; C07C303/40 ; C07D207/404 ; C07D295/112 ; C07D207/06 ; A61P7/02 ; A61P29/00 ; A61P9/06 ; A61P9/10 ; A61P3/04 ; A61P35/00
摘要：
The invention relates to novel compounds of formula I where R1, R2, R3, R4, R5, R9, Ar, Q1, Q2 and Q3 are each as defined below. The compounds of the formula I have antithrombotic activity and inhibit especially protease-activated receptor 1 (PAR1). The invention further relates to a process for preparing the compound of the formula I and to the use thereof as a medicament.