发明申请
- 专利标题： PRODUCTION OF GALACTOSYLATED GLYCOPROTEINS IN LOWER EUKARYOTES
- 专利标题（中）： 在较低的核酸中生产糖基化的糖蛋白
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申请号： US12840529申请日： 2010-07-21
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公开(公告)号： US20110053214A1公开(公告)日： 2011-03-03
- 发明人: Robert Collier Davidson , Tillman Ulf Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen Robin Hamilton
- 申请人： Robert Collier Davidson , Tillman Ulf Gerngross , Stefan Wildt , Byung-Kwon Choi , Juergen Hermann Nett , Piotr Bobrowicz , Stephen Robin Hamilton
- 申请人地址： US NH Lebanon
- 专利权人： GLYCOFI, INC.
- 当前专利权人： GLYCOFI, INC.
- 当前专利权人地址： US NH Lebanon
- 主分类号： C12P21/02
- IPC分类号： C12P21/02 ; C12N9/16 ; C12N9/42 ; C12N9/72 ; C12N9/50 ; C07K14/56 ; C07K14/755 ; C07K16/00 ; C07K14/435 ; C07K2/00 ; C07K14/475 ; C07K14/565 ; C07K14/57 ; C07K14/555 ; C07K14/535 ; C07K14/54 ; C07K14/60 ; C07K14/485 ; C07K14/59
摘要：
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal β-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein.
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