发明申请
- 专利标题: AGLYCOSYLATED IMMUNOGLOBULIN MUTANTS
- 专利标题(中): 易分解的免疫球蛋白突变体
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申请号: US12746411申请日: 2008-12-05
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公开(公告)号: US20110059075A1公开(公告)日: 2011-03-10
- 发明人: K. Dane Wittrup , Jeffrey Ravetch , Stephen Lael Sazinsky
- 申请人: K. Dane Wittrup , Jeffrey Ravetch , Stephen Lael Sazinsky
- 申请人地址: US MA Cambridge
- 专利权人: Massachusetts Institute of Technology
- 当前专利权人: Massachusetts Institute of Technology
- 当前专利权人地址: US MA Cambridge
- 国际申请: PCT/US2008/085757 WO 20081205
- 主分类号: A61K39/395
- IPC分类号: A61K39/395 ; C07K16/00 ; C07H21/00 ; C12N15/63 ; C12N5/10 ; C40B30/04 ; A61P37/02
摘要:
The present invention is based, in part, on our discovery of immunoglobulins (e.g., immunoglobulin G (IgG)) polypeptides (e.g., murine or human IgG, such as human IgG1) that are aglycosylated yet retain the ability to bind to an Fc receptor, such as an activating Fc receptor (e.g., Fcy RIIA and/or FcyRIIIA).
公开/授权文献
- US08815237B2 Aglycosylated immunoglobulin mutants 公开/授权日:2014-08-26
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