发明申请
US20110059093A1 USE OF AN ANTI-TAU PS422 ANTIBODY FOR THE TREATMENT OF BRAIN DISEASES
有权
使用抗谷氨酸PS422抗体治疗脑疾病
- 专利标题： USE OF AN ANTI-TAU PS422 ANTIBODY FOR THE TREATMENT OF BRAIN DISEASES
- 专利标题（中）： 使用抗谷氨酸PS422抗体治疗脑疾病
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申请号： US12792810申请日： 2010-06-03
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公开(公告)号： US20110059093A1公开(公告)日： 2011-03-10
- 发明人: Bernd Bohrmann , Ulrich Goepfert , Fiona Grueninger , Walter Huber , Hans-Willi Krell , Valeria Lifke , Olaf Mundigl , Sonja Offner , Laurence Ozmen , Michael Schraeml
- 申请人： Bernd Bohrmann , Ulrich Goepfert , Fiona Grueninger , Walter Huber , Hans-Willi Krell , Valeria Lifke , Olaf Mundigl , Sonja Offner , Laurence Ozmen , Michael Schraeml
- 优先权： EP09007656.3 20090610; EP09008487.2 20090630
- 主分类号： A61K39/395
- IPC分类号： A61K39/395 ; C07K16/00 ; A61P25/00 ; A61P25/28 ; C07H21/00 ; C12P21/04
摘要：
An antibody binding to Tau that is phosphorylated at serine 422 (pS422), which specifically binds to phosphorylated Tau fragment of SEQ ID NO:9 and to Tau pS422, but does not bind to Tau and to phosphorylated MCAK fragment of SEQ ID NO:17. The antibody is useful in the treatment of a Tauopathy.
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