Invention Application
- Patent Title: MODULATORS OF ALPHA-SYNUCLEIN TOXICITY
- Patent Title (中): ALPHA-SYNUCLEIN毒素的调节剂
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Application No.: US12809859Application Date: 2008-12-22
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Publication No.: US20110064722A1Publication Date: 2011-03-17
- Inventor: Susan L. Lindquist , Aaron D. Gitler
- Applicant: Susan L. Lindquist , Aaron D. Gitler
- Applicant Address: US MA Cambridge
- Assignee: Whitehead Institute for Miomedical Reasearch
- Current Assignee: Whitehead Institute for Miomedical Reasearch
- Current Assignee Address: US MA Cambridge
- International Application: PCT/US08/88022 WO 20081222
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C12N5/071 ; C12Q1/02 ; C12Q1/68 ; C12N5/10 ; C12N1/19 ; G01N33/53 ; A61K31/7088 ; A61K38/02 ; G01N33/68 ; C07K16/18 ; C07H21/00 ; A61P25/00 ; A61P25/28 ; A61P25/16
Abstract:
Disclosed are genes that, when overexpressed in cells expressing alpha-synuclein, either suppress or enhance alpha-synuclein mediated cellular toxicity. Compounds that modulate expression of these genes or activity of the encoded proteins can be used to inhibit alpha-synuclein mediated toxicity and used to treat or prevent synucleinopathies such as Parkinson's disease. Also disclosed are methods of identifying inhibitors of alpha-synuclein mediated toxicity.
Public/Granted literature
- US08501465B2 Modulators of alpha-synuclein toxicity Public/Granted day:2013-08-06
Information query
