发明申请
US20110077230A1 COPPER ORGANOCOMPLEXES, USE THEREOF AS ANTITUMOR MEANS AND FOR PROTECTING HEALTHY TISSUE FROM IONIZING RADIATION
审中-公开
铜离子化合物作为抗肿瘤手段使用，并用于保护健康组织从离子辐射
- 专利标题： COPPER ORGANOCOMPLEXES, USE THEREOF AS ANTITUMOR MEANS AND FOR PROTECTING HEALTHY TISSUE FROM IONIZING RADIATION
- 专利标题（中）： 铜离子化合物作为抗肿瘤手段使用，并用于保护健康组织从离子辐射
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申请号： US12918131申请日： 2009-02-20
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公开(公告)号： US20110077230A1公开(公告)日： 2011-03-31
- 发明人: Valeriy Tatarskiy , Aram Prokop
- 申请人： Valeriy Tatarskiy , Aram Prokop
- 申请人地址： DE Potsdam DE Berlin
- 专利权人： VALERIY TATARSKIY,CHARITE - UNIVERSITATSMEDIZIN BERLIN
- 当前专利权人： VALERIY TATARSKIY,CHARITE - UNIVERSITATSMEDIZIN BERLIN
- 当前专利权人地址： DE Potsdam DE Berlin
- 优先权： EP08151840.9 20080222
- 国际申请： PCT/EP2009/052073 WO 20090220
- 主分类号： A61K31/555
- IPC分类号： A61K31/555 ; C07F1/08 ; A61K31/30 ; A61P35/00
摘要：
The present invention relates to copper-organic complexes and pharmaceutical compositions containing the same. They can be used especially in the treatment of diseases caused by hyperproliferative cells and, in addition, protect healthy tissue from ionizing radiation. They are prepared by reacting a copper(II) acylate with an organic compound selected from 4-[bis(2-chloroethyl)amino]-D,L-phenyl-alanine (sarcolysine), the hydrochloride thereof, N-(2-furanidil)-5-fluorouracil (tegafur) and aminocarbonylaziridine (leacadin) at acidic to neutral pH in a chloroform/methanol mixture.
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