公开(公告)号：US20110077230A1

公开(公告)日：2011-03-31

申请号：US12918131

申请日：2009-02-20

申请人： Valeriy Tatarskiy ,  Aram Prokop

发明人： Valeriy Tatarskiy ,  Aram Prokop

IPC分类号： A61K31/555 ,  C07F1/08 ,  A61K31/30 ,  A61P35/00

CPC分类号： C07F1/005

摘要： The present invention relates to copper-organic complexes and pharmaceutical compositions containing the same. They can be used especially in the treatment of diseases caused by hyperproliferative cells and, in addition, protect healthy tissue from ionizing radiation. They are prepared by reacting a copper(II) acylate with an organic compound selected from 4-[bis(2-chloroethyl)amino]-D,L-phenyl-alanine (sarcolysine), the hydrochloride thereof, N-(2-furanidil)-5-fluorouracil (tegafur) and aminocarbonylaziridine (leacadin) at acidic to neutral pH in a chloroform/methanol mixture.

摘要翻译： 本发明涉及铜 - 有机络合物和含有它们的药物组合物。 它们可以特别用于治疗由过度增殖细胞引起的疾病，另外还可以保护健康组织免受电离辐射。 它们通过使酰基铜（II）与选自4- [双（2-氯乙基）氨基] -D，L-苯基 - 丙氨酸（肉碱）的有机化合物，其盐酸盐，N-（2-呋喃糖苷 ）-5-氟尿嘧啶（替加氟）和氨基羰基氮丙啶（leacadin）在酸性至中性pH下在氯仿/甲醇混合物中的溶液。

公开(公告)号：US20090005338A1

公开(公告)日：2009-01-01

申请号：US11942659

申请日：2007-11-19

申请人： Andreas Gansauer ,  Aram Prokop ,  Anja Selig ,  Dieter Franke

发明人： Andreas Gansauer ,  Aram Prokop ,  Anja Selig ,  Dieter Franke

IPC分类号： A61K31/7068 ,  C07F17/00 ,  A61P35/00 ,  A61P31/00 ,  A61P37/00 ,  A61P29/00 ,  A61K31/28

CPC分类号： A61K31/28 ,  A61K31/7008 ,  C07F17/00 ,  Y02A50/411 ,  A61K2300/00

摘要： A medicament containing a compound of the following formulas (Ia) and (Ib): wherein Z is selected from the group consisting of a covalent bond, at least one at least divalent hetero atom, a saturated, unsaturated, branched, unbranched and/or cyclic, substituted or unsubstituted hydrocarbon chain, a saturated or unsaturated, branched, unbranched and/or cyclic, substituted or unsubstituted hydrocarbon chain provided with hetero atoms in the chain thereof, or combinations thereof; R′1 to R′4 and R″1 to R″5 independently represent H, at least one hetero atom, especially oxygen, nitrogen or halogens, a saturated, unsaturated, branched, unbranched and/or cyclic, substituted or unsubstituted hydrocarbon chain, a saturated or unsaturated, branched, unbranched and/or cyclic, substituted or unsubstituted hydrocarbon chain provided with hetero atoms in the chain thereof, or combinations thereof; the two cyclopentadienyl rings are optionally linked together via any of residues R″1 to R″5; R1 and R2 independently represent H, a hetero atom, especially oxygen, nitrogen or halogens, a saturated, unsaturated, branched, unbranched and/or cyclic, substituted or unsubstituted hydrocarbon chain, a saturated or unsaturated, branched, unbranched and/or cyclic, substituted or unsubstituted hydrocarbon chain provided with hetero atoms in the chain thereof, or combinations thereof; A′, A″ is independently F, Cl, Br, I and/or a physiologically acceptable acid residue of an organic or inorganic acid; n is a positive integer, especially 1, 2, 3; X=O, S, NH, NR3 or NH4R5, wherein R3, R4 and R5 independently have the meanings as mentioned above for R′1 to R′4; Y is a covalent bond, O, S or NR6, wherein R6 has the meanings as mentioned above for R′1 to R′4.

摘要翻译： 含有下式（Ia）和（Ib）化合物的药物：其中Z选自共价键，至少一个至少二价杂原子，饱和，不饱和，支链，无支链和/或 环状，取代或未取代的烃链，在其链中提供有杂原子的饱和或不饱和，支链，无支链和/或环状，取代或未取代的烃链，或其组合; R'1至R'4和R'1至R'5独立地表示H，至少一个杂原子，特别是氧，氮或卤素，饱和，不饱和，支链，未分支和/或环状，取代或未取代的 烃链，在其链中提供有杂原子的饱和或不饱和，支链，非支链和/或环状，取代或未取代的烃链，或其组合; 两个环戊二烯基环任选地通过残基R'1至R'5任意连接在一起; 饱和的，不饱和的，支链的，无支链的和/或环状的取代或未取代的烃链，饱和或不饱和的，支链的，非支链的和/或环状的， 在其链中提供有杂原子的取代或未取代的烃链，或其组合; A'，A“独立地是F，Cl，Br，I和/或有机或无机酸的生理上可接受的酸残基; n是正整数，特别是1,2,3; X = O，S，NH，NR 3或NH 4 R 5，其中R 3，R 4和R 5独立地具有如上对R'1至R'4所述的含义; Y是共价键，O，S或NR 6，其中R 6具有如上对R'1至R'4所述的含义。