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    COPPER ORGANOCOMPLEXES, USE THEREOF AS ANTITUMOR MEANS AND FOR PROTECTING HEALTHY TISSUE FROM IONIZING RADIATION
    1.
    发明申请
    COPPER ORGANOCOMPLEXES, USE THEREOF AS ANTITUMOR MEANS AND FOR PROTECTING HEALTHY TISSUE FROM IONIZING RADIATION 审中-公开
    铜离子化合物作为抗肿瘤手段使用，并用于保护健康组织从离子辐射

    公开(公告)号：US20110077230A1

    公开(公告)日：2011-03-31

    申请号：US12918131

    申请日：2009-02-20

    申请人： Valeriy Tatarskiy ,  Aram Prokop

    发明人： Valeriy Tatarskiy ,  Aram Prokop

    IPC分类号： A61K31/555 ,  C07F1/08 ,  A61K31/30 ,  A61P35/00

    CPC分类号： C07F1/005

    摘要： The present invention relates to copper-organic complexes and pharmaceutical compositions containing the same. They can be used especially in the treatment of diseases caused by hyperproliferative cells and, in addition, protect healthy tissue from ionizing radiation. They are prepared by reacting a copper(II) acylate with an organic compound selected from 4-[bis(2-chloroethyl)amino]-D,L-phenyl-alanine (sarcolysine), the hydrochloride thereof, N-(2-furanidil)-5-fluorouracil (tegafur) and aminocarbonylaziridine (leacadin) at acidic to neutral pH in a chloroform/methanol mixture.

    摘要翻译： 本发明涉及铜 - 有机络合物和含有它们的药物组合物。 它们可以特别用于治疗由过度增殖细胞引起的疾病，另外还可以保护健康组织免受电离辐射。 它们通过使酰基铜（II）与选自4- [双（2-氯乙基）氨基] -D，L-苯基 - 丙氨酸（肉碱）的有机化合物，其盐酸盐，N-（2-呋喃糖苷 ）-5-氟尿嘧啶（替加氟）和氨基羰基氮丙啶（leacadin）在酸性至中性pH下在氯仿/甲醇混合物中的溶液。