发明申请
- 专利标题: PYRIDONE COMPOUNDS
- 专利标题(中): 吡咯烷酮化合物
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申请号: US12999379申请日: 2009-06-16
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公开(公告)号: US20110082133A1公开(公告)日: 2011-04-07
- 发明人: Takashi Kamikubo , Masanori Miura , Takao Okuda , Keisuke Maki , Fukushi Hirayama , Ayako Moritomo , Yuriko Komiya , Keisuke Matsuura , Ryotaro Ibuka
- 申请人: Takashi Kamikubo , Masanori Miura , Takao Okuda , Keisuke Maki , Fukushi Hirayama , Ayako Moritomo , Yuriko Komiya , Keisuke Matsuura , Ryotaro Ibuka
- 优先权: JP2008-157818 20080617
- 国际申请: PCT/JP2009/060925 WO 20090616
- 主分类号: A61K31/5415
- IPC分类号: A61K31/5415 ; A61K31/4725 ; A61K31/4439 ; A61K31/4412 ; C07D417/06 ; A61P9/10 ; A61K31/444 ; C07D417/12 ; C07D401/06 ; C07D211/72
摘要:
[Problems] A useful compound which can be used as a pharmaceutical, in particular, an agent for treating peripheral arterial occlusive disease is provided.[Means for Solution] The present inventors have conducted extensive studies on EP4 receptor agonists, and as a result, have found that a novel pyridone compound, in which a group having an acidic group is substituted at the 1-position of the pyridone ring, the 6-position is bonded with an aromatic ring group via a linking part, and the linking part contains a nitrogen atom, has an excellent EP4 receptor agonistic action, thereby completing the present invention. Since the compound of the present invention has an excellent EP4 receptor agonistic action, it is useful as a pharmaceutical, in particular, as an agent for treating peripheral arterial occlusive disease.
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