发明申请
- 专利标题: PROCESS FOR PRODUCING BICYCLOANILINE DERIVATIVES
- 专利标题(中): 生产双氰胺衍生物的方法
-
申请号: US12996801申请日: 2009-06-02
-
公开(公告)号: US20110092520A1公开(公告)日: 2011-04-21
- 发明人: Shuntaro Furukawa , Taketo Ikeno , Shinji Kato , Masashi Kawasaki , Hisaki Kojima , Wataru Minagawa , Naotaka Sawada , Fuyuki Yamamoto , Sachin Lohani , Yaling Wang
- 申请人: Shuntaro Furukawa , Taketo Ikeno , Shinji Kato , Masashi Kawasaki , Hisaki Kojima , Wataru Minagawa , Naotaka Sawada , Fuyuki Yamamoto , Sachin Lohani , Yaling Wang
- 国际申请: PCT/US09/45917 WO 20090602
- 主分类号: A61K31/519
- IPC分类号: A61K31/519 ; C07D487/04 ; C07D221/04 ; A61P35/00
摘要:
The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
公开/授权文献
- US08507504B2 Process for producing bicycloaniline derivatives 公开/授权日:2013-08-13
信息查询
IPC分类: