摘要:
The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
摘要:
The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
摘要:
The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide and novel salts, hydrates and polymorphs thereof.
摘要:
The present invention relates to a process for producing crystalline trans-N-[1-(2-fluorophenyl)-S-pyrazoly]-3-ox-ospiro[6-azaisobenzofuran-1(3H),1′-cyclohexane]-4′-carboxamide and novel salts, hydrates and polymorphs thereof.
摘要:
An image forming apparatus includes a photoconductor, an optical scanner, a development device, a movable density sensor, a density sensor driver, and a processor. The optical scanner includes a light source to emit light, and irradiates a surface of the photoconductor in a main scanning direction with the light to form a latent image on the surface of the photoconductor. The development device develops the latent image into a toner image. The density sensor detects unevenness in density of the toner image in the main scanning direction. The density sensor driver moves the density sensor in the main scanning direction. The processor corrects a driving signal for the light source according to image data to reduce the unevenness in density in the main scanning direction, according to positional data of the density sensor in the main scanning direction and an output value of the density sensor.
摘要:
An image forming apparatus includes an image bearer; a toner image forming device; a transfer rotator; a transfer device; a rotation position detector; an image density detector; a density data acquisition unit to causes the toner image forming device to form an adjustment toner image equal to or greater in length than a circumferential length of the image bearer, cause a linear velocity difference between the image bearer and the transfer rotator in transfer of the adjustment toner image, and acquires, from a detected image density of the toner image transferred from the image bearer, detected by the image density detector, image density unevenness data with reference to detection of a reference rotation position of one of the image bearer and a rotator; and a correction unit to adjust an image forming condition according to the reference rotation position, the image density unevenness data, and the linear velocity difference.
摘要:
An image forming apparatus includes a latent image carrier; a charger; a charging power supply; a latent image writer to write; a developing device; a rotary attitude sensor; a controller to perform a data formulating process to formulate a change pattern data and a bias changing process to cause the charging power supply to change the charging bias output based on readings from the rotary attitude sensor and the change pattern data, during a print job; and a surface potential sensor to detect a surface potential of the latent image carrier. In the data formulating process, the controller formulates the change pattern data based on the surface potential of the latent image carrier detected by the surface potential sensor, while the charging power supply outputting a constant charging bias, and based on readings from the rotary attitude sensor while the surface potential is being detected.
摘要:
The wiring-harness routing device 1 includes two wiring harness 10, a support body 3 mounted slidably at a rail 2 and supporting a seat, and a protector 4 sliding interlockingly with the support body 3 and leading the two wiring harnesses 10 to the seat. The protector 4 includes a pair of wiring-harness hold portion 43 holding the two wiring harnesses 10 led through an opening 20 into the rail 2 to be arranged in parallel; a lead portion arranged between the pair of wiring-harness hold portions 43, and passing the two wiring harnesses 10 therethrough, and extending with a cylindrical shape so as to go through the slit and be led to an outside of the rail 2; and a mount portion 68 attached at the support body 3 so as to have a gap allowing motion in the widthwise direction of the rail 2.
摘要:
An image forming apparatus includes an image carrier; an image forming unit; a processor for controlling the image forming unit according to a predetermined image forming condition setting data; an image density sensor to detect an image density of the toner pattern formed on the image carrier; a reference rotary position detector; an image density fluctuation data acquisition unit to obtain an image density fluctuation data of more than one circumferential length of the photoreceptor drum with reference to the reference rotary position detected by the reference rotary position detector based on a result related to the toner pattern formed on the image carrier detected by the image density sensor; and a correction data generator to generate a correction data to correct a reference image forming condition setting data with a correction amount corresponding to each rotary position of the rotary member to thus reduce the image density fluctuation.
摘要:
An image forming apparatus includes an image carrier; a developer carrier configured to adhere toner onto the image carrier; an image density detector to detect a density of an image on the image carrier formed by the developer carrier adhering the toner on the image carrier; a rotary member to form an image pattern of which density is detected by the image density detector; and a rotational position detector to detect a rotational position of the rotary member. In the image forming apparatus, the image pattern is generated based on the rotational position detected by the rotational position detector and the rotary member that the rotational position detector detects the rotational position thereof is either the image carrier or the developer carrier.