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公开(公告)号:US09278938B2
公开(公告)日:2016-03-08
申请号:US14123381
申请日:2012-06-14
申请人: Yoichi Kawabata , Yasuhiro Sawai , Kazuaki Kanno , Naotaka Sawada
发明人: Yoichi Kawabata , Yasuhiro Sawai , Kazuaki Kanno , Naotaka Sawada
IPC分类号: C07D233/64 , C07D487/04
CPC分类号: C07D487/04 , C07D233/64
摘要: The present invention provides an advantageous production method of an imidazole derivative, which is suitable for industrial production.Compound (VI) is produced by reacting compound (I) with a Grignard reagent or a magnesium reagent, and a lithium reagent, and then reacting the resulting compound with compound (V).
摘要翻译: 本发明提供了适用于工业生产的咪唑衍生物的有利制备方法。 化合物(VI)通过使化合物(I)与格氏试剂或镁试剂和锂试剂反应,然后使所得化合物与化合物(V)反应来制备。
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公开(公告)号:US20150174555A1
公开(公告)日:2015-06-25
申请号:US14416962
申请日:2012-08-10
申请人: Iwao Nitta , Naotaka Sawada
发明人: Iwao Nitta , Naotaka Sawada
CPC分类号: B01J23/75 , B01D53/944 , B01D2255/104 , B01D2255/2047 , B01D2255/2073 , B01D2255/20738 , B01D2255/20746 , B01D2255/20753 , B01D2255/20761 , B01D2255/2092 , B01D2255/405 , B01D2255/407 , B01D2255/908 , B01J23/005 , B01J23/10 , B01J23/755 , B01J23/78 , B01J23/8892 , B01J23/8913 , B01J23/894 , B01J35/0006 , B01J35/0013 , B01J35/002 , B01J35/006 , B01J35/023 , B01J35/026 , B01J37/0203 , B01J37/0207 , B01J37/024 , B01J37/035 , B01J37/036 , B01J37/04 , B01J37/08
摘要: An exhaust gas purifying catalyst obtained by loading a solid material composed of M (M is a metal element selected from Cu, Mn, Ni, Fe, Mg and Ag), Co and O on a support having an oxygen absorbing/releasing ability through a thin layer containing Al and O; and a method for producing the catalyst above, including steps of coating the surface of the support having an oxygen absorbing/releasing ability with a precursor for giving a thin layer containing Al and O, and depositing a precursor of a solid material composed of M, Co and O, which is produced from an acid salt of Co and an acid salt of a metal M (M is a metal element selected from Cu, Mn, Ni, Fe, Mg and Ag).
摘要翻译: 将由M(M是选自Cu,Mn,Ni,Fe,Mg和Ag的金属元素)的固体材料,Co和O负载在具有氧吸收/释放能力的载体上的废气净化催化剂通过 含有Al和O的薄层; 以及上述催化剂的制造方法,包括以下步骤:将具有氧吸收/释放能力的载体的表面用前体赋予含有Al和O的薄层,并沉积由M组成的固体材料的前体, Co和O,其由Co的酸性盐和金属M的酸盐(M是选自Cu,Mn,Ni,Fe,Mg和Ag的金属元素)生成。
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公开(公告)号:US20150005160A1
公开(公告)日:2015-01-01
申请号:US14372344
申请日:2012-06-18
申请人: Iwao Nitta , Naotaka Sawada
发明人: Iwao Nitta , Naotaka Sawada
IPC分类号: B01J23/83
CPC分类号: B01J23/83 , B01D53/944 , B01D2255/104 , B01D2255/2047 , B01D2255/2065 , B01D2255/20746 , B01D2255/20753 , B01D2255/20761 , B01D2255/20792 , B01D2255/2092 , B01D2255/40 , B01D2255/405 , B01D2255/407 , B01J23/75 , B01J23/78 , B01J23/80 , B01J35/04 , B01J37/03 , Y02A50/2341
摘要: Provided is a non-noble metal-based exhaust gas purifying catalyst which is capable of removing an unreacted material such as carbon monoxide in an exhaust gas at low temperatures. An exhaust gas purifying catalyst of the present invention contains a ceria-based carrier and a complex oxide of cobalt and an additional metal element, said complex oxide being supported by the ceria carrier. The additional metal element contains a metal element that is selected from the group consisting of copper, silver, magnesium, nickel, zinc and combinations of these elements.
摘要翻译: 提供一种能够在低温下排出废气中的未反应物质如一氧化碳的非贵金属型废气净化催化剂。 本发明的废气净化催化剂含有二氧化铈系载体和钴与附加金属元素的复合氧化物,所述复合氧化物由二氧化铈载体负载。 另外的金属元素含有选自铜,银,镁,镍,锌以及这些元素的组合的金属元素。
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公开(公告)号:US20140100373A1
公开(公告)日:2014-04-10
申请号:US14123381
申请日:2012-06-14
申请人: Yoichi Kawabata , Yasuhiro Sawai , Kazuaki Kanno , Naotaka Sawada
发明人: Yoichi Kawabata , Yasuhiro Sawai , Kazuaki Kanno , Naotaka Sawada
IPC分类号: C07D233/64 , C07D487/04
CPC分类号: C07D487/04 , C07D233/64
摘要: The present invention provides an advantageous production method of an imidazole derivative, which is suitable for industrial production.Compound (VI) is produced by reacting compound (I) with a Grignard reagent or a magnesium reagent, and a lithium reagent, and then reacting the resulting compound with compound (V).
摘要翻译: 本发明提供了适用于工业生产的咪唑衍生物的有利制备方法。 化合物(VI)通过使化合物(I)与格氏试剂或镁试剂和锂试剂反应,然后使所得化合物与化合物(V)反应来制备。
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公开(公告)号:US20110092520A1
公开(公告)日:2011-04-21
申请号:US12996801
申请日:2009-06-02
申请人: Shuntaro Furukawa , Taketo Ikeno , Shinji Kato , Masashi Kawasaki , Hisaki Kojima , Wataru Minagawa , Naotaka Sawada , Fuyuki Yamamoto , Sachin Lohani , Yaling Wang
发明人: Shuntaro Furukawa , Taketo Ikeno , Shinji Kato , Masashi Kawasaki , Hisaki Kojima , Wataru Minagawa , Naotaka Sawada , Fuyuki Yamamoto , Sachin Lohani , Yaling Wang
IPC分类号: A61K31/519 , C07D487/04 , C07D221/04 , A61P35/00
CPC分类号: C07D487/04
摘要: The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
摘要翻译: 本发明涉及一种3-(2,6-二氯苯基)-4-亚氨基-7 - [(2'-甲基-2',3'-二氢-1'H-螺[环丙烷 -1,4'-异喹啉] -7'-基)氨基] -3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H) - 酮(化合物A)或化合物A的药学上可接受的盐 以及化合物A或化合物A的药学上可接受的盐的结晶形式,其可用于治疗各种癌症作为激酶抑制剂,特别是作为威尔激酶抑制剂的领域。
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公开(公告)号:US20090306375A1
公开(公告)日:2009-12-10
申请号:US11921726
申请日:2006-06-07
申请人: Satoshi Kii , Tsuyoshi Nagase , Kimihiko Sato , Nagaaki Sato , Naotaka Sawada , Takayuki Tsuritani
发明人: Satoshi Kii , Tsuyoshi Nagase , Kimihiko Sato , Nagaaki Sato , Naotaka Sawada , Takayuki Tsuritani
IPC分类号: C07D239/72
CPC分类号: C07D401/12
摘要: The present invention provides a process for producing a 4(3H)-quinazolinone derivative, which is useful as a medicinal substance, with better efficiency in an industrial scale. The process comprises the steps of reacting 4-hydroxy-N-tert-butoxycarbonylpiperidine with 4-fluoro-1-nitrobenzene in the presence of sodium hydride, reacting the resulting product with cyclobutanone, reducing the resulting product to give 4-(1-cyclobutyl-4-piperidinyl)oxyaniline, and reacting this compound with 2-methyl-5-trifluoromethyl-4H-3,1-benzoxazin-4-one to give 3-{4-[(1-cyclobutyl-4-piperidinyl)oxy]phenyl}-2-methyl-5-trifluoromethyl-4(3H)-quinazolinone.
摘要翻译: 本发明提供一种可用作药物的4(3H) - 喹唑啉酮衍生物的方法,其工业规模效率更好。 该方法包括在氢化钠存在下使4-羟基-N-叔丁氧基羰基哌啶与4-氟-1-硝基苯反应的步骤,使所得产物与环丁酮反应,将所得产物还原得到4-(1-环丁基 -4-哌啶基)氧苯胺,并使该化合物与2-甲基-5-三氟甲基-4H-3,1-苯并恶嗪-4-酮反应,得到3- {4 - [(1-环丁基-4-哌啶基)氧基] 苯基} -2-甲基-5-三氟甲基-4(3H) - 喹唑啉酮。
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公开(公告)号:US09314775B2
公开(公告)日:2016-04-19
申请号:US14372344
申请日:2012-06-18
申请人: Iwao Nitta , Naotaka Sawada
发明人: Iwao Nitta , Naotaka Sawada
IPC分类号: B01J23/00 , B01J23/02 , B01J23/10 , B01J23/56 , B01J23/72 , B01J21/04 , B01J23/83 , B01J37/03 , B01D53/94 , B01J23/75 , B01J23/78 , B01J23/80 , B01J35/04
CPC分类号: B01J23/83 , B01D53/944 , B01D2255/104 , B01D2255/2047 , B01D2255/2065 , B01D2255/20746 , B01D2255/20753 , B01D2255/20761 , B01D2255/20792 , B01D2255/2092 , B01D2255/40 , B01D2255/405 , B01D2255/407 , B01J23/75 , B01J23/78 , B01J23/80 , B01J35/04 , B01J37/03 , Y02A50/2341
摘要: Provided is a non-noble metal-based exhaust gas purifying catalyst which is capable of removing an unreacted material such as carbon monoxide in an exhaust gas at low temperatures. An exhaust gas purifying catalyst of the present invention contains a ceria-based carrier and a complex oxide of cobalt and an additional metal element, said complex oxide being supported by the ceria carrier. The additional metal element contains a metal element that is selected from the group consisting of copper, silver, magnesium, nickel, zinc and combinations of these elements.
摘要翻译: 提供一种能够在低温下排出废气中的未反应物质如一氧化碳的非贵金属型废气净化催化剂。 本发明的废气净化催化剂含有二氧化铈系载体和钴与附加金属元素的复合氧化物,所述复合氧化物由二氧化铈载体负载。 另外的金属元素含有选自铜,银,镁,镍,锌以及这些元素的组合的金属元素。
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公开(公告)号:US08507504B2
公开(公告)日:2013-08-13
申请号:US12996801
申请日:2009-06-02
申请人: Shuntaro Furukawa , Taketo Ikeno , Shinji Kato , Masashi Kawasaki , Hisaki Kojima , Wataru Minagawa , Naotaka Sawada , Fuyuki Yamamoto , Sachin Lohani , Yaling Wang
发明人: Shuntaro Furukawa , Taketo Ikeno , Shinji Kato , Masashi Kawasaki , Hisaki Kojima , Wataru Minagawa , Naotaka Sawada , Fuyuki Yamamoto , Sachin Lohani , Yaling Wang
IPC分类号: C07D487/00 , A61K31/505
CPC分类号: C07D487/04
摘要: The present invention relates to a process for producing a hydrate of 3-(2,6-dichlorophenyl)-4-imino-7-[(2′-methyl-2′,3′-dihydro-1′H-spiro[cyclopropane-1,4′-isoquinolin]-7′-yl)amino]-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one (Compound A) or of a pharmaceutically acceptable salt of Compound A and a crystalline form of Compound A or of a pharmaceutically acceptable salt of Compound A, which are useful in the field of treatment of various cancers as a kinase inhibitor, especially as a Weel kinase inhibitor.
摘要翻译: 本发明涉及一种3-(2,6-二氯苯基)-4-亚氨基-7 - [(2'-甲基-2',3'-二氢-1'H-螺[环丙烷 -1,4'-异喹啉] -7'-基)氨基] -3,4-二氢嘧啶并[4,5-d]嘧啶-2(1H) - 酮(化合物A)或化合物A的药学上可接受的盐 以及化合物A或化合物A的药学上可接受的盐的结晶形式,其可用于治疗各种癌症作为激酶抑制剂,特别是作为威尔激酶抑制剂的领域。
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公开(公告)号:US20100222394A1
公开(公告)日:2010-09-02
申请号:US12679836
申请日:2008-09-25
申请人: Kenichi Asakawa , Naotaka Sawada , Takayuki Tsuritani , Toshiaki Mase , Keiji Takahashi , Takahiro Itoh , Feng Xu , Naoki Yoshikawa
发明人: Kenichi Asakawa , Naotaka Sawada , Takayuki Tsuritani , Toshiaki Mase , Keiji Takahashi , Takahiro Itoh , Feng Xu , Naoki Yoshikawa
IPC分类号: A61K31/4439 , C07D401/12 , C07D213/71 , A61P3/10 , A61P3/04
CPC分类号: C07D213/71 , C07D401/12 , C07D487/08
摘要: The present invention provides a more efficient industrial method for producing a pyrazol-3-yl-benzamide derivative expressed by a formula useful as medicine: wherein R2, R3 and R4 each independently represent a lower alkyl group.
摘要翻译: 本发明提供了用于制备由用作药物的式表示的吡唑-3-基 - 苯甲酰胺衍生物的更有效的工业方法:其中R2,R3和R4各自独立地表示低级烷基。
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公开(公告)号:US20060241299A1
公开(公告)日:2006-10-26
申请号:US10550136
申请日:2004-05-14
申请人: Ralph Volante , Steven Weissman , Takehiko Iida , Yuhei Yamamoto , Hiroki Sato , Kenji Maeda , Naotaka Sawada , Toshiaki Mase
发明人: Ralph Volante , Steven Weissman , Takehiko Iida , Yuhei Yamamoto , Hiroki Sato , Kenji Maeda , Naotaka Sawada , Toshiaki Mase
IPC分类号: C07D491/10
CPC分类号: C07D491/10
摘要: This invention relates to a process for making spirolactone compounds of general formula I, having an improved IA/IB ratio, according to the following shceme.
摘要翻译: 本发明涉及按照下列方法制备具有改进的IA / IB比的通式Ⅰ的己内酯化合物的方法。
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