发明申请
US20110097330A1 Novel Gene Disruptions, Compostitions and Methods Relating Thereto
审中-公开
新型基因破坏，组合和方法相关
- 专利标题： Novel Gene Disruptions, Compostitions and Methods Relating Thereto
- 专利标题（中）： 新型基因破坏，组合和方法相关
-
申请号： US11722967申请日： 2006-02-27
-
公开(公告)号： US20110097330A1公开(公告)日： 2011-04-28
- 发明人: Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
- 申请人： Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
- 申请人地址： US CA South San Francisco US TX The Woodlands
- 专利权人： Genentech, Inc.,Lexicon Pharmaceuticals, Inc.
- 当前专利权人： Genentech, Inc.,Lexicon Pharmaceuticals, Inc.
- 当前专利权人地址： US CA South San Francisco US TX The Woodlands
- 国际申请： PCT/US2006/007353 WO 20060227
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C07K16/18 ; A61K39/00 ; A61P25/00 ; A61P9/00 ; A61P37/00 ; A61P27/02 ; A61P25/24 ; A61P25/22 ; A61P25/18 ; A61P27/06 ; A61P27/12 ; A61P9/10 ; A61P19/02 ; A61P19/10 ; C12Q1/68 ; C12N5/071 ; C12N5/0735 ; C12Q1/02
摘要：
The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
信息查询
