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公开(公告)号:US20110097330A1
公开(公告)日:2011-04-28
申请号:US11722967
申请日:2006-02-27
申请人: Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
发明人: Allison Anne Byers Horner , Catherine Batac Clarke , Katherin E. Combs , Frederic J. de Sauvage , Joel Edwards , Paul Godowski , Deanna Grant Wilson , Wenhu Huang , Lorelei Diane Ketcherside , Erin Marie Massey , Charles Montgomery , Bobby Joe Payne , Andrew Peterson , Ni Nancy Qian , Jeffrey J. Schrick , Zheng-Zheng Shi , Mary Jean Sparks , Joy Anne Stala , Colleen M. Viator , Peter Vogel , Weilan Ye , Jung-Hua Yeh , Zhiyong Ding
IPC分类号: A61K49/00 , C07K16/18 , A61K39/00 , A61P25/00 , A61P9/00 , A61P37/00 , A61P27/02 , A61P25/24 , A61P25/22 , A61P25/18 , A61P27/06 , A61P27/12 , A61P9/10 , A61P19/02 , A61P19/10 , C12Q1/68 , C12N5/071 , C12N5/0735 , C12Q1/02
CPC分类号: C07K14/47 , A01K2217/075 , A61K2039/505 , G01N2500/00
摘要: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO179, PRO181, PRO244, PRO247, PRO269, PRO293, PRO298, PRO339, PRO341, PRO347, PRO531, PRO537, PRO718, PRO773, PRO860, PRO871, PRO872, PRO813, PRO828, PRO1100, PRO1114, PRO115, PRO1126, PRO1133, PRO1154, PRO1185, PRO1194, PRO1287, PRO1291, PRO1293, PRO1310, PRO1312, PRO1335, PRO1339, PRO2155, PRO1356, PRO1385, PRO1412, PRO1487, PRO1758, PRO1779, PRO1785, PRO1889, PRO90318, PRO3434, PRO3579, PRO4322, PRO4343, PRO4347, PRO4403, PRO4976, PRO260, PRO6014, PRO6027, PRO6181, PRO6714, PRO9922, PRO7179, PRO7476, PRO9824, PRO19814, PRO19836, PRO20088, PRO70789, PRO50298, PRO51592, PRO1757, PRO4421, PRO9903, PRO1106, PRO1411, PRO1486, PRO1565, PRO4399 or PRO4404 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
摘要翻译: 本发明涉及转基因动物,以及与基因功能表征相关的组合物和方法。 具体地说,本发明提供转基因小鼠,其包括PRO179,PRO181,PRO244,PRO247,PRO269,PRO293,PRO298,PRO339,PRO341,PRO347,PRO531,PRO537,PRO718,PRO773,PRO860,PRO871,PRO872,PRO813,PRO828,PRO1100中的中断 ,PRO1114,PRO115,PRO1126,PRO1133,PRO1154,PRO1185,PRO1194,PRO1287,PRO1291,PRO1293,PRO1310,PRO1312,PRO1335,PRO1339,PRO2155,PRO1356,PRO1385,PRO1412,PRO1487,PRO1758,PRO1779,PRO1785,PRO1889,PRO90318,PRO3434 ,PRO3579,PRO4322,PRO4343,PRO4347,PRO4403,PRO4976,PRO260,PRO6014,PRO6027,PRO6181,PRO6714,PRO9922,PRO7179,PRO7476,PRO9824,PRO19814,PRO19836,PRO20088,PRO70789,PRO50298,PRO51592,PRO1757,PRO4421,PRO9903,PRO1106 ,PRO1411,PRO1486,PRO1565,PRO4399或PRO4404基因。 这样的体内研究和表征可以提供有用的识别和发现治疗和/或治疗用于预防,改善或矫正与基因中断相关的疾病或功能障碍如神经障碍; 心血管,内皮或血管生成障碍; 眼睛异常; 免疫学障碍; 肿瘤疾病; 骨代谢异常或障碍; 脂代谢紊乱 或发育异常。
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公开(公告)号:US20050188378A1
公开(公告)日:2005-08-25
申请号:US10851923
申请日:2004-05-21
申请人: Lawrence Miller , James Lempenau , Leonid Shtivelman , William Deans , Marc Le Gelebart , Andrew Peterson
发明人: Lawrence Miller , James Lempenau , Leonid Shtivelman , William Deans , Marc Le Gelebart , Andrew Peterson
CPC分类号: H04L67/16 , G06F9/544 , H04L63/0869 , H04L63/123
摘要: A system and method that provides a JPeX client that opens up a socket on which it listens for connections from the local host. External applications on the desktop are able to connect to the server socket in the client and use XML to execute commands on the client.
摘要翻译: 提供一个JPeX客户端的系统和方法,该客户端打开一个套接字,监听来自本地主机的连接。 桌面上的外部应用程序能够连接到客户端中的服务器套接字,并使用XML在客户端上执行命令。
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公开(公告)号:US5411861A
公开(公告)日:1995-05-02
申请号:US842465
申请日:1992-02-27
申请人: Brian Seed , Andrew Peterson
发明人: Brian Seed , Andrew Peterson
IPC分类号: G01N33/53 , C07K7/08 , C07K14/00 , C07K14/435 , C07K14/705 , C07K14/73 , C12N5/10 , C12N7/04 , C12N15/09 , C12N15/10 , C12P21/02 , C12R1/91 , G01N33/569 , G01N33/577 , G01N33/68 , C12Q1/68
CPC分类号: C12N15/1086 , C07K14/70514 , C12N15/1034 , G01N33/56972 , G01N33/56988 , G01N33/6878
摘要: A novel rapid mutational analysis method for mapping protein epitopes is disclosed. This method has been used to identify the binding sites for 16 anti-CD2 and anti-CD4 monoclonal antibodies. The powerful, rapid, and simple method of the present invention allows isolation of a very large number of mutants, and is applicable to any intracellular or surface protein for which a cDNA and monoclonal antibodies are available. The present method is especially useful in ligand binding site studies for the design of new ligands and drugs.
摘要翻译: 公开了一种用于测定蛋白质表位的新型快速突变分析方法。 该方法已被用于鉴定16种抗CD2和抗CD4单克隆抗体的结合位点。 本发明的强大,快速和简单的方法允许分离非常大量的突变体,并且可应用于可获得cDNA和单克隆抗体的任何细胞内或表面蛋白质。 本方法在配体结合位点研究中特别适用于新配体和药物的设计。
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公开(公告)号:US20100205737A1
公开(公告)日:2010-08-19
申请号:US12370596
申请日:2009-02-13
申请人: Andrew Peterson
发明人: Andrew Peterson
CPC分类号: A47C17/72
摘要: A collapsible cot with support legs that folds under the cot. This allows the cot support fabric to be attached at the ends of the support rails and keep the support fabric tight. This eliminates the need to have and extra support bar across the front and back of the cot.
摘要翻译: 一个可折叠的婴儿床,支撑腿折叠在婴儿床下面。 这使得婴儿床支撑织物在支撑轨道的端部附接并且使支撑织物保持紧密。 这样就不需要在婴儿床的前面和后面都有和额外的支撑杆。
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公开(公告)号:US06767278B1
公开(公告)日:2004-07-27
申请号:US10624142
申请日:2003-07-21
申请人: Andrew Peterson
发明人: Andrew Peterson
IPC分类号: E06B702
摘要: A support bas assembly has a first bar and a second bar. Each bar has a outdoor face, a parallel indoor face, a horizontal planar upper face, a parallel lower face, a free end and a central end. The central end of the second bar is slidably received within the central end of the first bar. Secured to the outdoor face of the first bar adjacent to the central end is a locking assembly.
摘要翻译: 支撑底座组件具有第一杆和第二杆。 每个条具有室外面,平行的室内面,水平平面上表面,平行下表面,自由端和中心端。 第二杆的中心端可滑动地容纳在第一杆的中心端内。 固定在与中心端相邻的第一条的室外面是锁定组件。
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公开(公告)号:US06579676B1
公开(公告)日:2003-06-17
申请号:US09400207
申请日:1999-09-21
申请人: Brian Seed , Andrew Peterson
发明人: Brian Seed , Andrew Peterson
IPC分类号: C12N1563
CPC分类号: C12N15/1086 , C07K14/70514 , C12N15/1034 , G01N33/56972 , G01N33/56988 , G01N33/6878
摘要: A novel rapid mutational analysis method for mapping protein epitopes is disclosed. This method has been used to identify the binding sites for 16 anti-CD2 and anti-CD4 monoclonal antibodies. The powerful, rapid, and simple method of the present invention allows isolation of a very large number of mutants, and is applicable to any intracellular or surface protein for which a cDNA and monoclonal antibodies are available. The present method is especially useful in ligand binding site studies for the design of new ligands and drugs.
摘要翻译: 公开了一种用于测定蛋白质表位的新型快速突变分析方法。 该方法已被用于鉴定16种抗CD2和抗CD4单克隆抗体的结合位点。 本发明的强大,快速和简单的方法允许分离非常大量的突变体,并且可应用于可获得cDNA和单克隆抗体的任何细胞内或表面蛋白质。 本方法在配体结合位点研究中特别适用于新配体和药物的设计。
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公开(公告)号:US20140096845A1
公开(公告)日:2014-04-10
申请号:US13644276
申请日:2012-10-04
申请人: Andrew Peterson
发明人: Andrew Peterson
IPC分类号: F16K21/04
CPC分类号: A45F3/18 , Y10T137/7837
摘要: Embodiments of the apparatus is a personal hydration apparatus comprising a drink manifold with a receptor configured such that a water tight seal can form between a threaded bottle and the receptor. A check valve is coupled to the drink manifold configure to allow air into manifold and a first tube coupled to the manifold that is configured to allow liquid to be drawn from the threaded bottle. The hydration manifold allows an individual the convenience of using a conventional bottle filled with liquid in a hydration system accessible through a hose.
摘要翻译: 该装置的实施方案是一种个人水合装置,其包括具有接收器的饮料歧管,其配置为使得在带螺纹的瓶子和受体之间形成防水密封。 止回阀联接到饮料歧管,其构造为允许空气进入歧管,并且联接到歧管的第一管被配置成允许液体从螺纹瓶中抽出。 水合歧管允许个人在通过软管可接近的水合系统中使用填充有液体的常规瓶子的方便。
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公开(公告)号:US20120128799A1
公开(公告)日:2012-05-24
申请号:US13361396
申请日:2012-01-30
IPC分类号: A23G3/52 , A23L1/30 , A23L1/304 , A61K36/00 , A23G3/36 , A23G3/42 , A61K47/26 , A23L1/27 , A23L1/308
摘要: Dried soft aerated confections and methods of their preparation are provided having a water activity of about 0.1 to 0.4 and a glass transition temperature of less than 20° C. The confections comprise sugars, a foaming and a structuring ingredient, preferably each gelatin, and about 5 to 15% softening agent. Preferred softening agents include glycerin, polyglycerols and mixtures thereof. The confections are aerated to densities of about 0.1 to 0.5 g/cc. The soft dried aerated confections are particularly suited for addition to children's Ready-To-Eat cereals in the form of pieces weighing about 0.1 to 2 g each. The dried confection pieces maintain their soft texture over time without causing moisture migration to the cereal.
摘要翻译: 提供干燥的充气甜食及其制备方法,其水活度为约0.1至0.4,玻璃化转变温度低于20℃。糖果包括糖,发泡和结构成分,优选每种明胶,约 5〜15%软化剂。 优选的软化剂包括甘油,聚甘油及其混合物。 甜食充气至约0.1至0.5g / cc的密度。 柔软干燥的充气甜食特别适合于以每个重约0.1至2克的碎片形式添加到儿童即食谷物中。 干燥的甜食片段随着时间的推移保持其柔软的质地,而不会导致水分迁移到谷物。
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公开(公告)号:US20110000017A1
公开(公告)日:2011-01-06
申请号:US12883648
申请日:2010-09-16
申请人: Andrew Peterson
发明人: Andrew Peterson
IPC分类号: A47C19/12
CPC分类号: A47C17/72
摘要: A collapsible cot with support legs that fold under the cot. This allows the cot support fabric to be attached at the ends of the support rails and keep the support fabric tight. This eliminates the need to have and extra support bar across the front and back of the cot.
摘要翻译: 一个可折叠的婴儿床,支撑腿折叠在婴儿床下面。 这使得婴儿床支撑织物在支撑轨道的端部附接并且使支撑织物保持紧密。 这样就不需要在婴儿床的前面和后面都有和额外的支撑杆。
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公开(公告)号:US20050183393A1
公开(公告)日:2005-08-25
申请号:US11116850
申请日:2005-04-28
申请人: Michael Engesser , Andrew Peterson , Steve White
发明人: Michael Engesser , Andrew Peterson , Steve White
CPC分类号: B65G65/463 , B65B1/12 , B65B9/20 , B65B37/10 , B65B39/007 , B65B2220/14 , B65G33/18
摘要: A dispensing apparatus is provided suitable for dispensing at least first and second components in desired ratios especially for multi-component packaged food products. The apparatus comprises a hopper having an outlet at its lower end and a first auger having a hollow shaft disposed within the hopper having component conveying flights and a drive means for rotating the auger. A first component is conveyed by the auger flights and dispensed at an outlet while a second component is conveyed though a hollow shaft of the auger. The apparatus can include a second rotationally driven auger that is positioned within the hollow shaft of the first auger having conveying flights. The second component can be conveyed via the second auger within the hollow shaft. The second auger's shaft also can be hollow whereby a third component can be conveyed through the second hollow shaft of the second auger. Also provided are methods for dispensing measured quantities of multiple components for providing blends of components characterized by highly uniform amounts of each component in each quantity of the blend. The components dispensed can be blended and packaged in a single container such as a film pouch or separately in a multi-compartment pouch.
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