发明申请
- 专利标题: 5-HYDROXYPYRIMIDINE-4-CARBOXAMIDE COMPOUND
- 专利标题(中): 5-羟基嘧啶-4-羧酰胺化合物
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申请号: US12988947申请日: 2009-04-21
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公开(公告)号: US20110112103A1公开(公告)日: 2011-05-12
- 发明人: Takeshi Kuribayashi , Hideki Kubota , Takeshi Fukuda , Rieko Takano , Takashi Tsuji , Koji Sasaki , Naoki Tanaka
- 申请人: Takeshi Kuribayashi , Hideki Kubota , Takeshi Fukuda , Rieko Takano , Takashi Tsuji , Koji Sasaki , Naoki Tanaka
- 申请人地址: JP Tokyo
- 专利权人: DAIICHI SANKYO COMPANY, LIMITED
- 当前专利权人: DAIICHI SANKYO COMPANY, LIMITED
- 当前专利权人地址: JP Tokyo
- 优先权: JP2008-111562 20080422
- 国际申请: PCT/JP2009/057937 WO 20090421
- 主分类号: A61K31/513
- IPC分类号: A61K31/513 ; C07D401/06 ; C07D401/14 ; C07D409/14 ; C07D417/14 ; C07D413/14 ; C07D403/14 ; C07D405/14 ; C07D401/10 ; C07D405/06 ; A61P7/06
摘要:
The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R1 represents a group —X-Q1, X-Q1-Y-Q2 or X-Q1-Y-Q2-Z-Q3, X represents a single bond, —CH2— or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH2—, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR11R12— or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].
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