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公开(公告)号:US20110112103A1
公开(公告)日:2011-05-12
申请号:US12988947
申请日:2009-04-21
申请人: Takeshi Kuribayashi , Hideki Kubota , Takeshi Fukuda , Rieko Takano , Takashi Tsuji , Koji Sasaki , Naoki Tanaka
发明人: Takeshi Kuribayashi , Hideki Kubota , Takeshi Fukuda , Rieko Takano , Takashi Tsuji , Koji Sasaki , Naoki Tanaka
IPC分类号: A61K31/513 , C07D401/06 , C07D401/14 , C07D409/14 , C07D417/14 , C07D413/14 , C07D403/14 , C07D405/14 , C07D401/10 , C07D405/06 , A61P7/06
CPC分类号: C07D239/34 , C07D239/52 , C07D239/56 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/06 , C07D405/06 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/06 , C07D417/14 , C07D451/02 , C07D471/04
摘要: The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R1 represents a group —X-Q1, X-Q1-Y-Q2 or X-Q1-Y-Q2-Z-Q3, X represents a single bond, —CH2— or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH2—, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR11R12— or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].
摘要翻译: 本发明提供促进促红细胞生成素生成的化合物。 提供了由以下通式(1)表示的化合物或其药理学上可接受的盐:[其中,R1表示-X-Q1,X-Q1-Y-Q2或X-Q1-Y-Q2-Z-Q3, X表示单键,-CH 2 - 等,Q 1表示可具有取代基的单环或双环杂环基,Y表示单键,-CH 2 - 等,Q 2表示单环或双环烃 可以具有取代基的环基或可以具有取代基的单环或双环杂环基,Z表示单键,-CR 11 R 12 - 等,R 11和R 12各自独立地表示氢原子,卤素原子 Q3表示可具有取代基的苯基,可具有取代基的C3-C7环烷基,可具有取代基的C3-C7环烯基或单环或双环杂环 可以具有取代基的基团,R2表示C1-C3烷基等,R3表示 呈现氢原子或甲基]。
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公开(公告)号:US08222281B2
公开(公告)日:2012-07-17
申请号:US12893592
申请日:2010-09-29
申请人: Narihiro Toda , Masao Yoshida , Rieko Takano , Masahiro Inoue , Takeshi Honda , Koji Matsumoto , Ryutaro Nakashima
发明人: Narihiro Toda , Masao Yoshida , Rieko Takano , Masahiro Inoue , Takeshi Honda , Koji Matsumoto , Ryutaro Nakashima
IPC分类号: A61K31/44 , C07D211/94
CPC分类号: C07D207/325 , A61K31/192 , A61K31/195 , A61K31/196 , A61K31/275 , A61K31/343 , A61K31/40 , A61K31/4192 , A61K31/426 , A61K31/428 , A61K31/47 , A61K31/4741 , C07C59/66 , C07C59/72 , C07C205/34 , C07C205/37 , C07C217/76 , C07C229/42 , C07C255/54 , C07C311/29 , C07C317/22 , C07C2601/02 , C07C2602/08 , C07D215/22 , C07D249/04 , C07D277/24 , C07D277/64 , C07D307/83 , C07D491/048
摘要: To find a therapeutic agent and/or a preventive agent for diabetes mellitus or the like having excellent activity and safety. A compound represented by the following general formula (I), or a pharmacologically acceptable salt thereof. In the formula, X represents ═C(R5)- or ═N—; Y represents —O— or —NH—; L represents a bond or a substitutable C1-C3 alkylene group; M represents a substitutable C3-C10 cycloalkyl group, a substitutable C6-C10 aryl group, or a substitutable heterocyclic group; R1 represents a C1-C6 alkyl group, a C3-C10 cycloalkyl group, a C1-C6 haloalkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, a C1-C6 aliphatic acyl group, a C1-C6 alkoxy C1-C6 alkyl group, or a C6-C10 aryl group; and R2, R3, R4, and R5 may be the same or different and each represent a hydrogen atom, a halogen atom, a C1-C3 alkyl group, a C1-C3 haloalkyl group, a C1-C3 alkoxy group, or a nitro group. In this connection, the alkyl group moieties of R1 and R2 may be bonded to each other to form a 5- to 6-membered heterocyclic ring containing one oxygen atom.
摘要翻译: 找到具有优异活性和安全性的治疗剂和/或糖尿病预防剂等。 由以下通式(I)表示的化合物或其药理学上可接受的盐。 在该式中,X表示=(C)(R5) - 或= N-; Y表示-O-或-NH-; L表示键或可取代的C1-C3亚烷基; M表示可取代的C 3 -C 10环烷基,可取代的C 6 -C 10芳基或可取代的杂环基; R1表示C1-C6烷基,C3-C10环烷基,C1-C6卤代烷基,C2-C6烯基,C2-C6炔基,C1-C6脂肪族酰基,C1-C6烷氧基 C1-C6烷基或C6-C10芳基; R2,R3,R4和R5可以相同或不同,表示氢原子,卤素原子,C1-C3烷基,C1-C3卤代烷基,C1-C3烷氧基或硝基 组。 就此而言,R 1和R 2的烷基部分可以相互结合形成含有一个氧原子的5-至6-元杂环。
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