摘要:
The present invention provides compounds which promote erythropoietin production. Compounds represented by the following general formula (1) or pharmacologically acceptable salts thereof are provided: [wherein, R1 represents a group —X-Q1, X-Q1-Y-Q2 or X-Q1-Y-Q2-Z-Q3, X represents a single bond, —CH2— or the like, Q1 represents a monocyclic or bicyclic heterocyclic group which may have substituent(s), Y represents a single bond, —CH2—, or the like, Q2 represents a monocyclic or bicyclic hydrocarbon ring group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), Z represents a single bond, —CR11R12— or the like, R11 and R12 each independently represents a hydrogen atom, a halogen atom or the like, Q3 represents a phenyl group which may have substituent(s), a C3-C7 cycloalkyl group which may have substituent(s), a C3-C7 cycloalkenyl group which may have substituent(s) or a monocyclic or bicyclic heterocyclic group which may have substituent(s), R2 represents a C1-C3 alkyl group or the like, and R3 represents a hydrogen atom or a methyl group].
摘要:
The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.
摘要:
The present invention provides a compound which enhances the production of erythropoietin. The present invention provides a compound represented by formula (1): [wherein, R1: formula (1A): [wherein, R4 and R5: H, halogen, or alkyl; R6: H, halogen, alkyl, or the like; R7: substitutable hydroxyalkyl, substitutable hydroxyhalo alkyl, substitutable alkoxyalkyl, or the like; substituent group α: oxo, hydroxy, amino, or the like; ring Q1: a monocyclic heterocyclic group; ring Q2: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; ring Q3: a monocyclic hydrocarbon ring group, or a monocyclic heterocyclic group; X: a single bond, methylene, ethylene, or the like]; R2: alkyl, or methylsulfanyl; and R3: H, or methyl], or the like.
摘要:
A shutter plate that is supported so as to be able to swing in both directions and covers both first and second operating parts, and a shutter mechanism that operates the shutter plate in one direction when the first operating part is to be exposed and in reverse direction when the second operating part is to be exposed are provided, wherein the shutter mechanism includes one pair of locking members for limiting or releasing the swing of the shutter plate.
摘要:
A shutter plate that is supported so as to be able to swing in both directions and covers both first and second operating parts, and a shutter mechanism that operates the shutter plate in one direction when the first operating part is to be exposed and in reverse direction when the second operating part is to be exposed are provided, wherein the shutter mechanism includes one pair of locking members for limiting or releasing the swing of the shutter plate.
摘要:
To obtain an air-conditioning apparatus that does not make a refrigerant circulate up to an indoor unit and further can achieve energy-saving. A refrigeration cycle is configured by connecting a compressor that pressurizes a refrigerant, a four-way valve that switches a circulation path of the refrigerant, a heat source side heat exchanger that performs heat exchange, expansion valves for pressure-adjusting the refrigerant, and a plurality of intermediate heat exchangers that performs heat exchange between the refrigerant and the heat medium to heat and cool the heat medium, with piping. A heat medium circuit is configured by connecting intermediate heat exchangers, pumps that pressurize the heat medium, and a plurality of use side heat exchangers that perform heat exchange between the heat medium and the air in the indoor space, with piping.
摘要:
A drive system with small power loss in power conversion is provided. The drive system has an AC conversion device for converting commercial AC power from a commercial AC power supply and a DC conversion device. An AC power supply path for supplying power to discharge tubes, and a DC power supply path for supplying power to an image processing circuit or the like, are provided independently. The AC conversion device converts commercial AC power into converted AC power and gives the converted AC power to an AC drive device directly. Consequently, it is possible to reduce conversion steps for generating converted AC power and to reduce power loss that occurs in a conversion process. In particular, when power consumption of the discharge tubes is large, it is possible to reduce power loss in an entire liquid crystal display apparatus effectively by providing the AC conversion device.
摘要:
A living body measurement system including a cerebral blood volume measurement unit for measuring a regional cerebral blood volume of a subject, an arterial pressure/heart rate measurement unit for measuring an arterial pressure and/or a heart rate of the subject, an analysis unit for analyzing signals measured by the cerebral blood volume measurement unit and the arterial pressure/heart rate measurement unit, an extraction unit for extracting information concerning a regional cerebral vascular state of the subject on the basis of an output of the analysis unit, and a display unit for displaying a measurement result measured by the cerebral blood volume measurement unit and/or the arterial pressure/heart rate measurement unit, an analysis result analyzed by the analysis unit, or an extraction result extracted by the extraction unit.
摘要:
A flat cable includes a signal line extending in a longitudinal direction, a thin dielectric sheet with which the signal line is coated and that has plasticity, a pair of spaced apart ground layers extending in the longitudinal direction and sandwiching the dielectric sheet in its thickness direction, and insulators that coat the pair of ground layers so that they are not exposed to the outside. The cross-sectional size of the signal line in a direction orthogonal to the longitudinal direction, the thickness and width of the dielectric sheet, and so forth are selected to obtain a predetermined characteristic impedance for the cable. Each of the pair of ground layers is sized so as to be substantially wider than the signal line.
摘要:
The present invention is concerned with an organic-inorganic composite graded material containing a composite material formed by chemically bonding an organic polymer compound and a metallic compound and having a component graded structure in which the content of the metallic compound continuously changes in the depth direction from the material surface, a process for the production of the above organic-inorganic composite graded material by forming a coating layer composed of a specific coating solution for forming the organic-inorganic composite film on an organic substrate and drying the coating layer under heat, a coating agent composed of the above organic-inorganic composite graded material for forming a coating film, and an article coated with the above coating agent.